Homoserine O-acetyltransferase

In enzymology, a homoserine O-acetyltransferase (EC 2.3.1.31) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + L-homoserine CoA + O-acetyl-L-homoserine
homoserine O-acetyltransferase
Identifiers
EC no.2.3.1.31
CAS no.9030-72-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are acetyl-CoA and L-homoserine, whereas its two products are CoA and O-acetyl-L-homoserine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:L-homoserine O-acetyltransferase. Other names in common use include homoserine acetyltransferase, homoserine transacetylase, homoserine-O-transacetylase, and L-homoserine O-acetyltransferase. This enzyme participates in methionine metabolism and sulfur metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2B61.

References

    • Nagai S, Flavin M (1967). "Acetylhomoserine. An intermediate in the fungal biosynthesis of methionine". J. Biol. Chem. 242 (17): 3884–95. PMID 6037552.


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