Howard Green (physician)

Howard Green (September 10, 1925 – October 31, 2015) was an American scientist, and George Higginson Professor of Cell Biology at Harvard Medical School.

Howard Green
Born(1925-09-10)September 10, 1925
Toronto
DiedOctober 31, 2015(2015-10-31) (aged 90)
Boston, Massachusetts
Alma materUniversity of Toronto
Known forstem-cell research, skin culture
SpouseRosine Kauffmann
AwardsMarch of Dimes Prize in Developmental Biology
Scientific career
InstitutionsNew York University School of Medicine,
Massachusetts Institute of Technology,
Harvard Medical School

He was the first to culture human cells in a laboratory setting for therapeutic use. He is one of the founding fathers of stem-cell research and regenerative medicine. One famous case involving Doctor Green concerned Jamie and Glenn Selby, two children from Wyoming who were burned over 95% of their bodies. Green cut small patches of undamaged skin from the boys, grew them in a lab and was able to harvest skin grafts to cover their burns.[1][2]

Education and personal life

Howard Green was born in 1925 in Toronto, Ontario. He graduated from University of Toronto medical school. He served in the United States Army. He taught at New York University School of Medicine, Massachusetts Institute of Technology from 1970 to 1980, and Harvard Medical School from 1980 to 1993.[3]

Green married Rosine Kauffmann Green née Kauffmann in 1954.[4]

He died on October 31, 2015, outside Boston, Massachusetts.

On November 23, 2016, Shriner's Hospitals for Children in Boston announced the opening of the Howard Green Center for Children's Skin Health and Research, funded by a $3 million gift from his wife, Mrs. Rosine Kauffmann Green.[5][6]

Academic positions held

Harvard Medical School

George Higginson Professor of Cell Biology

Chairman - Department of Cellular and Molecular Physiology 1980-1993

Head of Green Lab

Massachusetts Institute of Technology

Professor of Cell Biology[7]

New York University School of Medicine

Faculty member of the Department of Pathology[7]

Awards and honors
Award Year
March of Dimes Prize in Developmental Biology[8][9][10] 2012
Warren Alpert Foundation Prize[11] 2010
Blaise Pascal Award in Medical and Life Sciences of the European Academy of Sciences[12] 2007
Legion of Honour[13] 2001
Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research[14] 1979
Selman A. Waksman Award in Microbiology For his fundamental contributions to the biology of cultured animal cells. 1978
Member, National Academy of Sciences[15] 1978

Publications

Book

Therapy with Cultured Cells - book published 2010[16]

Selected academic articles
Date Title Journal
May 1, 1963 The Growth of Mouse Embryo Cells In Culture and Their Development into Established Lines [17] The Journal of Cell Biology
November 1975 Serial Cultivation of Strains of Human Epidermal Keratinocytes: The Formation of Keratinzing Colonies from Single Cells[18] Cell
November 1979 Growth of cultured human epidermal cells into multiple epithelia suitable for grafting[19] Proceedings of the National Academy of Sciences of the United States of America
January 10, 1981 Grafting of Burns with Cultured Epithelium Prepared from Autologous Epidermal Cells[20] The Lancet

References
  1. "Howard Green". www.warrenalpert.org. Retrieved 2015-10-18.
  2. "Howard Green, Who Found a Way to Grow Skin and Saved Lives, Dies at 90". The New York Times. November 5, 2015.
  3. Roberts, Sam (2015-11-05). "Howard Green, Who Found a Way to Grow Skin and Saved Lives, Dies at 90". The New York Times. ISSN 0362-4331. Retrieved 2015-12-17.
  4. "Howard Green dies at 90; Harvard scientist developed technique for regenerating human skin". Los Angeles Times. 10 November 2015. Retrieved 2015-12-17.
  5. "The Howard Green Center for Children's Skin Health and Research is dedicated to advancing the field of regenerative medicine". www.shrinershospitalsforchildren.org. Retrieved 2016-02-25.
  6. "Shriners Hospitals for Children". www.shrinershospitalsforchildren.org. Retrieved 2016-02-25.
  7. "Howard Green Department of Pathology". www.med.nyu.edu. Retrieved 2015-10-17.
  8. "March of Dimes" (PDF). March of Dimes - Prize Award Recipient History. March of Dimes. Retrieved 2015-10-17.
  9. "March of Dimes Awards $250,000 Prize to Two Scientists Who Pioneered Advances in Skin Disorders | March of Dimes". www.marchofdimes.org. Retrieved 2015-10-17.
  10. "Harvard biologist Dr. Howard Green's $250,000 prize - The Boston Globe". BostonGlobe.com. Retrieved 2015-10-17.
  11. "Prize Recipients | warrenalpert.org". www.warrenalpert.org. Retrieved 2015-10-17.
  12. "European Academy of Sciences - Blaise Pascal Medals 2007". www.eurasc.org. Archived from the original on 2011-01-19. Retrieved 2015-10-17.
  13. "DR. HOWARD GREEN's Obituary on". Boston Globe. Retrieved 2015-12-17.
  14. "Past Winners | Rosenstiel Award | Rosenstiel Basic Medical Sciences Research Center | Brandeis University". www.brandeis.edu. Retrieved 2015-10-18.
  15. "Howard Green". www.nasonline.org. Archived from the original on 2015-11-08. Retrieved 2015-10-17.
  16. Green, Howard (2010-03-31). Therapy with Cultured Cells (1 ed.). Singapore: Pan Stanford. ISBN 9789814267700.
  17. Green, Howard (May 1, 1963). "Quantitative Studies of the Growth of Mouse Embryo Cells in Culture and Their Development into Established Lines". The Journal of Cell Biology. 17 (2): 299–313. doi:10.1083/jcb.17.2.299. PMC 2106200. PMID 13985244.
  18. Green, Howard (November 1975). "Serial Cultivation of Strains of Human Keratinocytes: the Formation of Keratinizing Colonies from Single Cells" (PDF). Cell. 6 (3): 331–343. doi:10.1016/s0092-8674(75)80001-8. PMID 1052771. S2CID 53294766. Retrieved 2015-10-17.
  19. Green, Howard (November 1979). "Growth of cultured human epidermal cells into multiple epithelia suitable for grafting". Proceedings of the National Academy of Sciences of the United States of America. 76 (11): 5665–5668. Bibcode:1979PNAS...76.5665G. doi:10.1073/pnas.76.11.5665. PMC 411710. PMID 293669.
  20. O'Connor, Nicholase.; Mulliken, Johnb.; Banks-Schlegel, Susan; Kehinde, Olaniyi; Green, Howard (1981-01-10). "Grafting of Burns with Cultured Epithelium Prepared from Autologous Epidermal Cells". The Lancet. 317 (8211): 75–78. doi:10.1016/S0140-6736(81)90006-4. S2CID 22718432.
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