Hybrid oncocytoma/chromophobe renal cell carcinoma

Hybrid oncocytoma/chromophobe renal cell carcinoma
Hybrid oncocytoma/chromophobe renal cell carcinoma
Specialty	Oncology/Nephrology

Hybrid oncocytoma/chromophobe renal cell carcinoma is rare subtype of renal cell carcinoma.[1] It arises from intercalated cells of cortical collecting ducts of the kidney. It is associated with extreme hypodiploidy with multiple losses of entire chromosomes 1, 2, 6, 10, 13, 17, 21 and Y.

References

Ruiz-Cordero, Roberto; Rao, Priya; Li, Lerong; Qi, Yuan; Atherton, Daniel; Peng, Bo; Singh, Rajesh R.; Kim, Tae-Beom; Kawakami, Fumi; Routbort, Mark J.; Alouch, Nail; Chow, Chi-Wan B.; Tang, Ximing; Lu, Wei; Brimo, Fadi; Matin, Surena F.; Wood, Christopher G.; Tannir, Nizar M.; Wistuba, Ignacio I.; Chen, Ken; Wang, Jing; Medeiros, L. Jeffrey; Karam, Jose A.; Tamboli, Pheroze; Sircar, Kanishka (November 2019). "Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma". Modern Pathology. 32 (11): 1698–1707. doi:10.1038/s41379-019-0304-y. ISSN 1530-0285.

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[1] Ruiz-Cordero, Roberto; Rao, Priya; Li, Lerong; Qi, Yuan; Atherton, Daniel; Peng, Bo; Singh, Rajesh R.; Kim, Tae-Beom; Kawakami, Fumi; Routbort, Mark J.; Alouch, Nail; Chow, Chi-Wan B.; Tang, Ximing; Lu, Wei; Brimo, Fadi; Matin, Surena F.; Wood, Christopher G.; Tannir, Nizar M.; Wistuba, Ignacio I.; Chen, Ken; Wang, Jing; Medeiros, L. Jeffrey; Karam, Jose A.; Tamboli, Pheroze; Sircar, Kanishka (November 2019). "Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma". Modern Pathology. 32 (11): 1698–1707. doi:10.1038/s41379-019-0304-y. ISSN 1530-0285.