Hydroxystilbamidine

Hydroxystilbamidine is a fluorescent dye that emits different frequencies of light when bound to DNA and RNA. It is used as a retrograde tracer[1] for outlining neurons, and as a histochemical stain.

Hydroxystilbamidine
Names
Preferred IUPAC name
4-[(E)-2-(4-Carbamimidoylphenyl)ethen-1-yl]-3-hydroxybenzene-1-carboximidamide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.007.102
UNII
  • InChI=1S/C16H16N4O/c17-15(18)12-5-2-10(3-6-12)1-4-11-7-8-13(16(19)20)9-14(11)21/h1-9,21H,(H3,17,18)(H3,19,20)/b4-1+ checkY
    Key: TUESWZZJYCLFNL-DAFODLJHSA-N checkY
  • InChI=1/C16H16N4O/c17-15(18)12-5-2-10(3-6-12)1-4-11-7-8-13(16(19)20)9-14(11)21/h1-9,21H,(H3,17,18)(H3,19,20)/b4-1+
    Key: TUESWZZJYCLFNL-DAFODLJHBK
  • Oc2cc(ccc2/C=C/c1ccc(cc1)C(N)=N)C(N)=N
Properties
C16H16N4O
Molar mass 280.324 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references
PVH neurons of Long-Evans rat marked with fluoro-gold

References
  1. Naumann, Thomas (2000). "Retrograde tracing with Fluoro-Gold: different methods of tracer detection at the ultrastructural level and neurodegenerative changes of back-filled neurons in long-term studies". Journal of Neuroscience Methods. 103 (1): 11–21. doi:10.1016/S0165-0270(00)00292-2. PMID 11074092. S2CID 24155326.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.