IFIT3

Interferon-induced protein with tetratricopeptide repeats 3, also known as interferon-stimulated gene 49 (ISG49),[5] is a protein that in humans is encoded by the IFIT3 gene.[5][6][7][8] It plays a part in the innate immune response to viruses in response to type I interferon signaling.[5]

IFIT3
Identifiers
AliasesIFIT3, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41, interferon induced protein with tetratricopeptide repeats 3
External IDsOMIM: 604650 MGI: 1101055 HomoloGene: 1189 GeneCards: IFIT3
Orthologs
SpeciesHumanMouse
Entrez

3437

15959

Ensembl

ENSG00000119917

ENSMUSG00000074896

UniProt

O14879

Q64345

RefSeq (mRNA)

NM_001549
NM_001031683
NM_001289758
NM_001289759

NM_010501

RefSeq (protein)

NP_001026853
NP_001276687
NP_001276688
NP_001540

NP_034631

Location (UCSC)Chr 10: 89.33 – 89.38 MbChr 19: 34.56 – 34.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


References

  1. GRCh38: Ensembl release 89: ENSG00000119917 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000074896 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, et al. (2012). "Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis". PLoS Pathogens. 8 (5): e1002712. doi:10.1371/journal.ppat.1002712. PMC 3355090. PMID 22615570.
  6. de Veer MJ, Sim H, Whisstock JC, Devenish RJ, Ralph SJ (December 1998). "IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes". Genomics. 54 (2): 267–277. doi:10.1006/geno.1998.5555. PMID 9828129.
  7. Zhu H, Cong JP, Shenk T (December 1997). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs". Proceedings of the National Academy of Sciences of the United States of America. 94 (25): 13985–13990. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139.
  8. "Entrez Gene: IFIT3 interferon-induced protein with tetratricopeptide repeats 3".

Further reading


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