IGFALS

Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene.[5]

IGFALS
Identifiers
AliasesIGFALS, ALS, ACLSD, insulin like growth factor binding protein acid labile subunit
External IDsOMIM: 601489 MGI: 107973 HomoloGene: 37987 GeneCards: IGFALS
Orthologs
SpeciesHumanMouse
Entrez

3483

16005

Ensembl

ENSG00000099769

ENSMUSG00000046070

UniProt

P35858

P70389

RefSeq (mRNA)

NM_001146006
NM_004970

NM_008340
NM_001364895
NM_001364896

RefSeq (protein)

NP_001139478
NP_004961

NP_032366
NP_001351824
NP_001351825

Location (UCSC)Chr 16: 1.79 – 1.79 MbChr 17: 25.08 – 25.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Three transcript variants encoding two different isoforms have been found for this gene.[5]

Clinical significance

Defects in this gene are a cause of acid-labile subunit deficiency, which manifests itself in a delayed and slow puberty.

Interactions

IGFALS has been shown to interact with IGFBP3.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000099769 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000046070 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: IGFALS insulin-like growth factor binding protein, acid labile subunit".
  6. Twigg SM, Baxter RC (March 1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. 273 (11): 6074–9. doi:10.1074/jbc.273.11.6074. PMID 9497324.
  7. Firth SM, Ganeshprasad U, Baxter RC (January 1998). "Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3". J. Biol. Chem. 273 (5): 2631–8. doi:10.1074/jbc.273.5.2631. PMID 9446566.

Further reading


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