IK (gene)

IK
Identifiers
Aliases	IK, CSA2, RED, IK cytokine, down-regulator of HLA II, RER, IK cytokine
External IDs	OMIM: 600549 MGI: 1345142 HomoloGene: 36193 GeneCards: IK
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	140,662,480 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	36,890,692 bp[2]
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; sural nerve; ; Achilles tendon; ; ganglionic eminence; ; gastric mucosa; ; popliteal artery; ; right lung; ; monocyte; ; rectum;
	Top expressed in
	retinal pigment epithelium; ; Paneth cell; ; ciliary body; ; fossa; ; condyle; ; iris; ; supraoptic nucleus; ; superior cervical ganglion; ; ureter; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding;
Cellular component	nuclear speck; nuclear chromosome; mitotic spindle pole; spindle pole; nucleoplasm; spliceosomal complex; chromosome; cytoplasm; cytoskeleton; nucleus; U2-type precatalytic spliceosome;
Biological process	mitotic cell cycle; mitotic spindle assembly checkpoint signaling; protein localization to kinetochore; mRNA processing; RNA splicing; viral process; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	3550
	24010
	ENSG00000113141
	ENSMUSG00000024474
	Q13123; Q95HA6
	Q9Z1M8
	NM_006083
	NM_011879
	NP_006074; NP_006074.2
	NP_036009
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Red is a protein that in humans is encoded by the IK gene.[5][6]

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2.[6]

References

GRCh38: Ensembl release 89: ENSG00000113141 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024474 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Krief P, Augery-Bourget Y, Plaisance S, Merck MF, Assier E, Tanchou V, Billard M, Boucheix C, Jasmin C, Azzarone B (Dec 1994). "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization". Oncogene. 9 (12): 3449–56. PMID 7970704.
"Entrez Gene: IK IK cytokine, down-regulator of HLA II".

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