ILKAP

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.[5]

ILKAP
Identifiers
AliasesILKAP, ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase, PP2CD
External IDsMGI: 1914694 HomoloGene: 31525 GeneCards: ILKAP
Orthologs
SpeciesHumanMouse
Entrez

80895

67444

Ensembl

ENSG00000132323

ENSMUSG00000026309

UniProt

Q9H0C8

Q8R0F6

RefSeq (mRNA)

NM_030768
NM_176799

NM_023343
NM_001355152

RefSeq (protein)

NP_110395

NP_075832
NP_001342081

Location (UCSC)Chr 2: 238.17 – 238.2 MbChr 1: 91.37 – 91.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.[5]

Interactions

ILKAP has been shown to interact with Integrin-linked kinase.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000132323 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026309 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C".
  6. Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.

Further reading


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