INPP5F

INPP5F
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XUU
Identifiers
Aliases	INPP5F, MSTPO47, SAC2, hSAC2, MSTP007, inositol polyphosphate-5-phosphatase F
External IDs	OMIM: 609389 MGI: 2141867 HomoloGene: 8962 GeneCards: INPP5F
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	119,829,147 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	128,696,425 bp[2]
RNA expression pattern
	Top expressed in
	pons; ; superior vestibular nucleus; ; Brodmann area 23; ; orbitofrontal cortex; ; middle temporal gyrus; ; ventral tegmental area; ; secondary oocyte; ; Region I of hippocampus proper; ; parietal lobe; ; postcentral gyrus;
	Top expressed in
	nucleus accumbens; ; pontine nuclei; ; lateral hypothalamus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; globus pallidus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; suprachiasmatic nucleus; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	inositol monophosphate 1-phosphatase activity; inositol monophosphate phosphatase activity; protein homodimerization activity; inositol monophosphate 3-phosphatase activity; protein binding; phosphoric ester hydrolase activity; hydrolase activity; inositol monophosphate 4-phosphatase activity; phosphatidylinositol phosphate 4-phosphatase activity; phosphatidylinositol phosphate 5-phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity;
Cellular component	dendrite; clathrin-coated pit; membrane; clathrin-coated endocytic vesicle; cytoplasm; early endosome membrane; endosome; recycling endosome; early endosome; axon; neuronal cell body;
Biological process	phosphatidylinositol catabolic process; cardiac muscle hypertrophy in response to stress; regulation of protein kinase B signaling; phosphatidylinositol-mediated signaling; clathrin-dependent endocytosis; positive regulation of receptor recycling; phosphatidylinositol dephosphorylation; negative regulation of axon regeneration; phosphatidylinositol biosynthetic process; adult locomotory behavior; regulation of endocytic recycling; regulation of cell motility; negative regulation of peptidyl-serine phosphorylation; negative regulation of tyrosine phosphorylation of STAT protein;
	Sources:Amigo / QuickGO
Orthologs
	22876
	101490
	ENSG00000198825
	ENSMUSG00000042105
	Q9Y2H2
	Q8CDA1
	NM_001243194; NM_001243195; NM_014937
	NM_178641; NM_001346517
	NP_001230123; NP_001230124; NP_055752
	NP_001333446; NP_848756
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol polyphosphate-5-phosphatase F is a protein that in humans is encoded by the INPP5F gene.[5]

Function

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].

References

GRCh38: Ensembl release 89: ENSG00000198825 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042105 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Inositol polyphosphate-5-phosphatase F". Retrieved 2018-05-14.

Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA (December 2009). "Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness". Circ. Res. 105 (12): 1240–7. doi:10.1161/CIRCRESAHA.109.208785. PMC 2802340. PMID 19875726.
Kim HS, Li A, Ahn S, Song H, Zhang W (December 2014). "Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity". Sci Rep. 4: 7330. Bibcode:2014NatSR...4E7330K. doi:10.1038/srep07330. PMC 4256660. PMID 25476455.
Hsu F, Hu F, Mao Y (April 2015). "Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling". J. Cell Biol. 209 (1): 97–110. doi:10.1083/jcb.201408027. PMC 4395482. PMID 25869669.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198825 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042105 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Inositol polyphosphate-5-phosphatase F". Retrieved 2018-05-14.

INPP5F

Function

References

Further reading