INTS6

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.[5][6][7]

INTS6
Identifiers
AliasesINTS6, DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6
External IDsOMIM: 604331 MGI: 1202397 HomoloGene: 8121 GeneCards: INTS6
Orthologs
SpeciesHumanMouse
Entrez

26512

18130

Ensembl

ENSG00000102786

ENSMUSG00000035161

UniProt

Q9UL03

Q6PCM2

RefSeq (mRNA)

NM_001039937
NM_001039938
NM_001306091
NM_012141

NM_008715

RefSeq (protein)

NP_001035026
NP_001035027
NP_001293020
NP_036273

NP_032741

Location (UCSC)Chr 13: 51.35 – 51.45 MbChr 14: 62.91 – 63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000102786 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035161 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi:10.1038/sj.onc.1202806. PMID 10467397.
  6. Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.
  7. "Entrez Gene: INTS6 integrator complex subunit 6".

Further reading


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