IPO8

Importin 8 is a protein that in humans is encoded by the IPO8 gene.[5]

IPO8
Identifiers
AliasesIPO8, RANBP8, importin 8, VISS
External IDsOMIM: 605600 MGI: 2444611 HomoloGene: 48430 GeneCards: IPO8
Orthologs
SpeciesHumanMouse
Entrez

10526

320727

Ensembl

ENSG00000133704

ENSMUSG00000040029

UniProt

O15397

Q7TMY7

RefSeq (mRNA)

NM_001190995
NM_006390

NM_001081113

RefSeq (protein)

NP_001177924
NP_006381

NP_001074582

Location (UCSC)Chr 12: 30.63 – 30.7 MbChr 6: 148.77 – 148.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

References

  1. GRCh38: Ensembl release 89: ENSG00000133704 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040029 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Importin 8".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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