IRF2BP2
Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene. [5]
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| Aliases | IRF2BP2, interferon regulatory factor 2 binding protein 2, CVID14 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 615332 MGI: 2443921 HomoloGene: 34290 GeneCards: IRF2BP2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
References
- GRCh38: Ensembl release 89: ENSG00000168264 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000051495 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Interferon regulatory factor 2 binding protein 2". Retrieved 2017-01-06.
Further reading
- Childs KS, Goodbourn S (2003). "Identification of novel co-repressor molecules for Interferon Regulatory Factor-2". Nucleic Acids Res. 31 (12): 3016–26. doi:10.1093/nar/gkg431. PMC 162335. PMID 12799427.
- Tinnikov AA, Yeung KT, Das S, Samuels HH (2009). "Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells". Cancer Res. 69 (4): 1375–82. doi:10.1158/0008-5472.CAN-08-2896. PMC 4264605. PMID 19190336.
- Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
- Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
- Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP (2011). "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity". Mol. Cell. Biol. 31 (14): 2889–901. doi:10.1128/MCB.00974-10. PMC 3133407. PMID 21576369.
- Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF (2011). "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2". PLOS ONE. 6 (8): e24100. Bibcode:2011PLoSO...624100T. doi:10.1371/journal.pone.0024100. PMC 3162591. PMID 21887377.
- Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012). "Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma". PLOS ONE. 7 (11): e49705. Bibcode:2012PLoSO...749705N. doi:10.1371/journal.pone.0049705. PMC 3504151. PMID 23185413.
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