ITPK1

ITPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q7D, 2ODT, 2QB5
Identifiers
Aliases	ITPK1, ITRPK1, inositol-tetrakisphosphate 1-kinase
External IDs	OMIM: 601838 MGI: 2446159 HomoloGene: 8588 GeneCards: ITPK1
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	93,116,320 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	102,671,189 bp[2]
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; amygdala; ; nucleus accumbens; ; sural nerve; ; Brodmann area 9; ; right coronary artery; ; caudate nucleus; ; gallbladder; ; monocyte; ; rectum;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; intestinal villus; ; ileum; ; duodenum; ; jejunum; ; entorhinal cortex; ; large intestine; ; colon; ; epithelium of stomach; ; pyloric antrum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; isomerase activity; metal ion binding; kinase activity; inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity; catalytic activity; inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity; inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity; inositol-3,4,6-trisphosphate 1-kinase activity; ATP binding; hydrolase activity; magnesium ion binding; inositol-1,3,4-trisphosphate 6-kinase activity; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol-1,3,4-trisphosphate 5-kinase activity; inositol tetrakisphosphate 1-kinase activity; inositol tetrakisphosphate 6-kinase activity;
Cellular component	cytosol; intracellular anatomical structure; apical plasma membrane; cytoplasm;
Biological process	phosphorylation; blood coagulation; inositol phosphate metabolic process; inositol trisphosphate metabolic process; neural tube development; signal transduction; dephosphorylation; necroptosis; inositol phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3705
	217837
	ENSG00000100605; ENSG00000274958
	ENSMUSG00000057963
	Q13572
	Q8BYN3
	NM_014216; NM_001142593; NM_001142594; NM_001363707
	NM_172584
	NP_001136065; NP_001136066; NP_055031; NP_001350636
	NP_766172
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.[5][6][7]

It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.[8][9]

References

ENSG00000274958 GRCh38: Ensembl release 89: ENSG00000100605, ENSG00000274958 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000057963 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wilson MP, Majerus PW (Aug 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". J Biol Chem. 271 (20): 11904–10. doi:10.1074/jbc.271.20.11904. PMID 8662638.
Yang X, Shears SB (Jan 2001). "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase". Biochem J. 351 (3): 551–5. doi:10.1042/0264-6021:3510551. PMC 1221393. PMID 11042108.
"Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase".
Saiardi A, Cockcroft S (2008). "Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels". Sci Signal. 1 (4): pe5. doi:10.1126/stke.14pe5. PMID 18272466. S2CID 36710246.
Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G (September 2007). "Integration of inositol phosphate signaling pathways via human ITPK1". J. Biol. Chem. 282 (38): 28117–25. doi:10.1074/jbc.M703121200. PMC 2244811. PMID 17616525.

Wilson MP, Sun Y, Cao L, Majerus PW (2001). "Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2". J. Biol. Chem. 276 (44): 40998–1004. doi:10.1074/jbc.M106605200. PMID 11533064.
Ho MW, Yang X, Carew MA, et al. (2002). "Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase". Curr. Biol. 12 (6): 477–82. doi:10.1016/S0960-9822(02)00713-3. PMID 11909533.
Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1". J. Biol. Chem. 277 (48): 45759–64. doi:10.1074/jbc.M208709200. PMID 12324474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sun Y, Mochizuki Y, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis". J. Biol. Chem. 278 (44): 43645–53. doi:10.1074/jbc.M300674200. PMID 12925536.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Qian X, Mitchell J, Wei SJ, et al. (2005). "The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase". Biochem. J. 389 (Pt 2): 389–95. doi:10.1042/BJ20050297. PMC 1175116. PMID 15762844.
Miller GJ, Wilson MP, Majerus PW, Hurley JH (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase". Mol. Cell. 18 (2): 201–12. doi:10.1016/j.molcel.2005.03.016. PMID 15837423.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] ENSG00000274958 GRCh38: Ensembl release 89: ENSG00000100605, ENSG00000274958 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057963 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8662638-5] Wilson MP, Majerus PW (Aug 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". J Biol Chem. 271 (20): 11904–10. doi:10.1074/jbc.271.20.11904. PMID 8662638.

[pmid11042108-6] Yang X, Shears SB (Jan 2001). "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase". Biochem J. 351 (3): 551–5. doi:10.1042/0264-6021:3510551. PMC 1221393. PMID 11042108.

[entrez-7] "Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase".

[pmid18272466-8] Saiardi A, Cockcroft S (2008). "Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels". Sci Signal. 1 (4): pe5. doi:10.1126/stke.14pe5. PMID 18272466. S2CID 36710246.

[pmid17616525-9] Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G (September 2007). "Integration of inositol phosphate signaling pathways via human ITPK1". J. Biol. Chem. 282 (38): 28117–25. doi:10.1074/jbc.M703121200. PMC 2244811. PMID 17616525.

ITPK1

References

Further reading