Imidazoleacetate—phosphoribosyldiphosphate ligase

In enzymology, an imidazoleacetate—phosphoribosyldiphosphate ligase (EC 6.3.4.8) is an enzyme that catalyzes a chemical reaction

ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate
Imidazoleacetate—phosphoribosyldiphosphate ligase
Identifiers
EC no.6.3.4.8
CAS no.37318-65-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The 3 substrates of this enzyme are ATP, imidazole-4-acetate, and 5-phosphoribosyl diphosphate, whereas its 4 products are ADP, phosphate, 1-(5-phosphoribosyl)imidazole-4-acetate, and diphosphate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming). This enzyme is also called 5-phosphoribosylimidazoleacetate synthetase. This enzyme participates in histidine metabolism.

References

    • Crowley GM (August 1964). "The enzymatic synthesis of 5'-phosphoribosylimidazoleacetic acid". The Journal of Biological Chemistry. 239: 2593–601. PMID 14235540.


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