Indy (gene)

Indy, short for I'm not dead yet, is a gene found in the fruit fly Drosophila melanogaster, an important model organism. Mutant versions of this gene have doubled the average life span of fruit flies in at least one set of experiments, but this result has been subject to controversy. Both Indy proteins are sodium sulfate symporters.[1] Its name originates from a well-known comic line in Monty Python and the Holy Grail.[2]

I'm not dead yet
Identifiers
OrganismDrosophila melanogaster
SymbolIndy
UniProtQ9VVT2
Search for
StructuresSwiss-model
DomainsInterPro
I'm not dead yet 2
Identifiers
OrganismDrosophila melanogaster
SymbolIndy-2
UniProtQ9VDQ0
Search for
StructuresSwiss-model
DomainsInterPro

Reduced expression of this gene in Drosophila melanogaster flies and C. elegans worms (P32739) modeled the effects on obesity and diabetes of caloric reduction in primates such as humans. A similar effect was seen with SLC13A5 (mIndy) knockouts of mice.[3][4][5][6]

See also

References
  1. Rogina B, Reenan RA, Nilsen SP, Helfand SL (15 December 2000). "Extended life-span conferred by cotransporter gene mutations in Drosophila". Science. 290 (5499): 2137–40. Bibcode:2000Sci...290.2137R. doi:10.1126/science.290.5499.2137. PMID 11118146.
  2. Niku M, Taipale M (25 March 2003). "Clever Drosophila gene names". Archived from the original on 3 February 2007. Retrieved 15 February 2007.
  3. "Diet, diabetes, and a gene called mINDY". Yale School of Medicine. Retrieved 25 May 2019.
  4. Willmes DM, Schumann T, Henke C, Kurzbach A, Luft F, Morawietz H, et al. (2018). "The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms". Journal of the American College of Cardiology. 71 (11S): A1813. doi:10.1016/S0735-1097(18)32354-4.
  5. Willmes DM, Daniels M, Kurzbach A, Lieske S, Bechmann N, Schumann T, et al. (2021). "The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms". JCI Insight. 6 (2): e136083. doi:10.1172/jci.insight.136083. PMC 7934862. PMID 33491666.
  6. "The longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation". Medical Xpress. 2021.


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