Integral monotopic protein
Integral monotopic proteins are permanently attached to the cell membrane from one side, and are a type of integral membrane protein (IMP).[1]
Three-dimensional structures of the following integral monotopic proteins have been determined:
- prostaglandin H2 syntheses 1 and 2 (cyclooxygenases)
- lanosterol synthase and squalene-hopene cyclase
- microsomal prostaglandin E synthase
- carnitine O-palmitoyltransferase 2
- Phosphoglycosyl transferase C
There are also structures of integral monotopic domains of transmembrane proteins:
References
- Fowler, Philip W.; Coveney, Peter V. (July 2006). "A Computational Protocol for the Integration of the Monotopic Protein Prostaglandin H2 Synthase into a Phospholipid Bilayer". Biophysical Journal. 91 (2): 401–410. doi:10.1529/biophysj.105.077784. PMC 1483072. PMID 16632499.
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