Intersectin 2

Intersectin-2 is a protein that in humans is encoded by the ITSN2 gene.[4][5][6]

ITSN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITSN2, PRO2015, SH3D1B, SH3P18, SWA, SWAP, intersectin 2
External IDsOMIM: 604464 MGI: 1338049 HomoloGene: 22627 GeneCards: ITSN2
Orthologs
SpeciesHumanMouse
Entrez

50618

20403

Ensembl

ENSG00000198399

ENSMUSG00000020640

UniProt

Q9NZM3

Q9Z0R6

RefSeq (mRNA)

NM_147152
NM_006277
NM_019595

NM_001198968
NM_001198969
NM_011365

RefSeq (protein)

n/a

Location (UCSC)n/aChr 12: 4.64 – 4.76 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.[6]

Interactions

ITSN2 has been shown to interact with Wiskott-Aldrich syndrome protein.[5]

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000020640 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Pucharcos C, Estivill X, de la Luna S (Aug 2000). "Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis". FEBS Lett. 478 (1–2): 43–51. doi:10.1016/S0014-5793(00)01793-2. PMID 10922467. S2CID 24683452.
  5. McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA (Dec 2001). "The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis". J Exp Med. 194 (12): 1777–87. doi:10.1084/jem.194.12.1777. PMC 2193569. PMID 11748279.
  6. "Entrez Gene: ITSN2 intersectin 2".

Further reading

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