Rifampicin/isoniazid/pyrazinamide

Rifampicin/isoniazid/pyrazinamide, also known as rifampin/isoniazid/pyrazinamide, and sold under the trade name Rifater, is a medication used to treat tuberculosis.[1] It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide.[1] It is used either by itself or along with other antituberculosis medication.[1] It is taken by mouth.[1]

Rifampicin/isoniazid/pyrazinamide
Combination of
RifampicinRifamycin antibiotic
IsoniazidAnti-tuberculosis medication
PyrazinamideAnti-tuberculosis medication
Clinical data
Trade namesRifater, Trifazid, others
AHFS/Drugs.comFDA Professional Drug Information
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • US: ℞-only
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
  • none
KEGG
  (verify)

Side effects are those of the underlying medications.[1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness.[2] Severe side effects include liver problems.[3] Use in those under the age of 15 may not be appropriate.[3] It is unclear if use in pregnancy is safe for the baby.[3]

Rifampicin/isoniazid/pyrazinamide was approved for medical use in the United States in 1994.[3] It is on the World Health Organization's List of Essential Medicines.[4]

Medical uses

The hope of a fixed-dose combination pill is to increase the likelihood that people will take all of three medications.[5] Also, if people forget to take one or two of their drugs, they might not then develop resistance to the remaining drugs.

Society and culture

It is manufactured by Aventis.

See also

References
  1. World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 143. hdl:10665/44053. ISBN 9789241547659.
  2. "Rifater Side Effects in Detail - Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
  3. "Rifater - FDA prescribing information, side effects and uses". www.drugs.com. October 2016. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
  4. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  5. Brown MJ, Sharma P, Bennett PN (30 July 2012). Clinical Pharmacology. Elsevier Health Sciences. p. 204. ISBN 978-0-7020-5113-5.
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