Isonocardicin synthase

In enzymology, an isonocardicin synthase (EC 2.5.1.38) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + nocardicin E 5'-methylthioadenosine + isonocardicin A
isonocardicin synthase
Identifiers
EC no.2.5.1.38
CAS no.118246-74-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and nocardicin E, whereas its two products are 5'-methylthioadenosine and isonocardicin A.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase. This enzyme is also called nocardicin aminocarboxypropyltransferase.

References

    • Wilson BA, Bantia S, Salituro GM, Reeve AM, Townsend CA (1988). "Cell-free biosynthesis of nocardicin A from nocardicin E and S-adenosylmethionine". J. Am. Chem. Soc. 110 (24): 8238–8239. doi:10.1021/ja00232a047.


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