Jürgen Hennig

Jürgen Klaus Hennig (born in Stuttgart, Germany on March 5, 1951) is a German chemist and medical physicist. Internationally he is considered to be one of the pioneers of Magnetic Resonance Imaging for clinical diagnostics. He is the Scientific Director of the Department of Diagnostic Radiology and Chairman of the Magnetic Resonance Development and Application Center (MRDAC) at the University Medical Center Freiburg. In the year 2003 he was awarded the Max Planck Research Award in the category of Biosciences and Medicine.

Jürgen Hennig (2010)

Biography

Scientific career

From 1969 to 1977 Hennig studied chemistry in Stuttgart, London, Munich and Freiburg. During the years from 1977 to 1981 he was employed as a scientist at the Institute for Physical Chemistry (IPC) of the University of Freiburg, where he completed his doctoral degree on NMR measurements of intramolecular exchange kinetics under the supervision of Herbert Zimmermann.[1] During this time Hennig first came into contact with Magnetic Resonance Imaging (MRI) at the inaugural lecture of his advisor Hans-Heinrich Limbach on the work of Paul Lauterbur, a subsequent winner of the Nobel Prize.[2]

From 1982 to 1983 Hennig was a post-doctoral student at the University of Zurich, where he worked in the area of CIDNP Spectroscopy. In 1982 he developed his first own NMR pulse sequence to measure intramolecular exchange processes.[3] During his time in Zurich Hennig decided to focus his future work in the area of NMR method development with less focus on chemistry.[2]

Hennig began his work at the University Medical Center Freiburg in 1984 as a scientific researcher in the Department of Diagnostic Radiology. There, in cooperation with the company Bruker Medizintechnik GmbH, he developed the RARE-Method.[4] In the year 1989 he completed his professorial thesis of “Special Imaging Techniques for the Nuclear Magnetic Resonance Tomography” at the Medical Faculty of the University of Freiburg.

In the year 1993, Hennig was appointed a professorship at the University Medical Center Freiburg as the head of the MR Tomography work group in the Department of Diagnostic Radiology. In 1998 he was designated as the Director of the Department of Imaging and Functional Medical Physics of the Department of Diagnostic Radiology. In 2001 he became Research Director of the Department of Diagnostic Radiology. In the same year he founded the Magnetic Resonance Development and Application Center (MRDAC) at the University Medical Center Freiburg. A cooptation at the School of Mathematics and Physics of the University of Freiburg followed in the year 2002.

In 2004 Hennig was appointed C4-Professor at the University Medical Center Freiburg and since then he is the Scientific Director of the Department of Diagnostic Radiology. The research group for research and development in MRI that he founded and headed since 1984 grew to approximately 80 employees by the end of 2012.

In 1999 Hennig was the President of the International Society for Magnetic Resonance in Medicine (ISMRM). Since 2008 he has been a joint affiliate to the Wisconsin Institute for Medical Research at the University of Wisconsin–Madison. Since 2011 he has been a member of the German Academy of Sciences Leopoldina.

Works

Hennig has written numerous fundamental research papers on the development of Magnetic Resonance Imaging (MRI).

Based on the CPMG multi-echo method, Hennig developed the RARE Sequence (Rapid Acquisition with Relaxation Enhancement) in 1984. Through his work the MR image acquisition time could be significantly reduced, which constituted an important step for its use in clinical routine. In addition, RARE offered the possibility to control the diagnostically relevant T2 contrast in MRI. The RARE method was first published in 1984 in the German journal “Der Radiologe”.[5] His first submission to an international journal was rejected, with the comment that this method had already been tested and wouldn’t work.[2] In the year 1986 international publications followed.[4][6] RARE is currently one of the standard methods used in clinical MRI. The method is also known by the acronyms TSE (Turbo Spin Echo) and FSE (Fast Spin Echo).

The Hyperecho method[7] was published by Hennig in 2001. With hyperechoes the Specific absorption rate (SAR) of a RARE sequence can be significantly reduced while the image quality is almost completely maintained. This is important for clinical MRI applications at high magnetic field strengths.

In 2008 Hennig published a concept for imaging with non-linear magnetic field gradients which allows increasing the image resolution in brain MRI in the outer image regions.[8]

He and his team also organize educative workshops under support of ESMRMB.[9]

Connections to Asia

In the year 1985 Hennig travelled to Guangzhou, China in order to set up one of the first MRI systems in China. With this the first MR image was taken in China on December 25, 1985.[2] Since then he has attended other MRI system installations in China.

Hennig has been president and founding member of the European-Chinese Society for Clinical Magnetic Resonance since 1993. He is honorary member of the Chinese Radiological Society. Hennig was awarded “Einstein Professor” of the Chinese Academy of Science in 2011. In 2010 he received the Tsung Ming Tu Award, which is the highest scientific award of Taiwan.

Since 2004 Hennig is a member of the Academy of Science of the Republic of Tatarstan. Furthermore, he maintains cooperations with Hong Kong, South Korea and Singapore.

Awards

Quotes

I did not have much of a feeling of being 'inventive', I was just applying what I had learned about spin physics during my days in physical chemistry to the task at hand.

— Jürgen Hennig, in „How RARE came to China“[2] on the development of the RARE method

The world (and the world of MR in particular) is full of 'impossible' things which turned out to become reality.

— Jürgen Hennig, in „Ultra high field MR: useful instruments or toys for the boys?“[14]

References
  1. J. Hennig (1980), Physikalisch-chemische Untersuchungen des Vibrationstunneleffektes bei der intramolekularen Wasserstoffwanderung in Tetraarylporphinen (in German), Freiburg{{citation}}: CS1 maint: location missing publisher (link)
  2. J. Hennig (2010), "How RARE Came to China: Early Days of MRI", Encyclopedia of Magnetic Resonance (in German), doi:10.1002/9780470034590.emrhp1025
  3. J. Hennig; H. H. Limbach (1982), "Magnetization transfer in the rotating frame: A new simple kinetic tool for the determination of rate constants in the slow chemical exchange range", J Magn Reson (in German), vol. 49, no. 2, pp. 322–328, Bibcode:1982JMagR..49..322H, doi:10.1016/0022-2364(82)90195-0
  4. J. Hennig; A. Nauerth; H. Friedburg (1986), "RARE imaging: A fast imaging method for clinical MR", Magn Reson Med (in German), vol. 3, no. 6, pp. 823–833, doi:10.1002/mrm.1910030602, PMID 3821461, S2CID 25261837
  5. J. Hennig; A. Nauerth; H. Friedburg; D. Ratzel (1984), "Ein neues Schnellbildverfahren für die Kernspintomographie", Radiologe (in German), vol. 24, pp. 579–580
  6. J. Hennig; H. Friedburg; B. Strobel (1986), "Rapid nontomographic approach to MR myelography without contrast agents", J Comput Assist Tomogr (in German), vol. 10, no. 3, pp. 375–378
  7. J. Hennig; K. Scheffler (2001), "Hyperechoes", Magn Reson Med (in German), vol. 46, no. 1, pp. 6–12, doi:10.1002/mrm.1153, PMID 11443704, S2CID 222021523
  8. J. Hennig; A. Welz; G. Schultz; J. Korvink; Z. Liu; O. Speck; M. Zaitsev (2008), "Parallel imaging in non-bijective, curvilinear magnetic field gradients: a concept study", Magn Reson Mater Phy (in German), vol. 21, no. 1–2, pp. 5–14, doi:10.1007/s10334-008-0105-7, PMC 2798019, PMID 18299913
  9. ".: ESMRMB - Online :.: Inverse imaging, sparse sampling, compressed sensing, and more". www.esmrmb.org. Archived from the original on 2015-10-04.
  10. Award winner list of the European Magnetic Resonance Award
  11. Gold Medal Award winner list International Society for Magnetic Resonance in Medicine
  12. "Hounsfield Memorial Lecture". www.hounsfieldlecture.org (in German). Archived from the original on 2016-07-21. Retrieved 2016-07-21.
  13. "Alfred-Breit-Preis | DRG.de". www.drg.de (in German). Retrieved 2016-07-21.
  14. J. Hennig (2008), "Ultra high field MR: useful instruments or toys for the boys?", Magn Reson Mater Phy (in German), vol. 21, no. 1–2, pp. 1–3, doi:10.1007/s10334-008-0109-3, PMID 18392650, S2CID 19921728
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