James Sinclair
James Sinclair may refer to:
- James Sinclair (footballer) (born 1987), English footballer
- Jimmy Sinclair (1876–1913), South African cricketer
- James Sinclair (politician) (1908–1984), Canadian politician
- James Sinclair (fur trader) (1811–1856), Canadian fur trapper
- James H. Sinclair (1871–1943), U.S. Congressman from North Dakota
- James Sinclair (conductor), American classical music conductor
- James Sinclair, 12th Earl of Caithness (1766–1823), Scottish noble
- James Sinclair, 14th Earl of Caithness (1821–1881), Scottish Liberal politician, scientist and inventor
- James Sinclair (botanist) (1913–1968), Scottish botanist
- James Sinclair, 8th Lord Sinclair, Scottish nobleman
- James Sinclair, English co-founder of EnterpriseAlumni
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