Jason Swedlow

Jason Swedlow is an American-born cell biologist and light microscopist who is Professor of Quantitative Cell Biology at the School of Life Sciences, University of Dundee, Scotland. He is a co-founder of the Open Microscopy Environment and Glencoe Software. In 2021, he joined Wellcome Leap as a Program Director.

Jason R. Swedlow
Born (1961-06-20) June 20, 1961
Los Angeles, CA
NationalityAmerican
Alma materUniversity of California, San Francisco
Known forOpen Microscopy Environment (OME)
AwardsBBSRC Innovator of the Year Fellow of the Royal Society of Edinburgh
Scientific career
FieldsCell Biology & Bioimage informatics
InstitutionsUniversity of Dundee
ThesisDistribution and Dynamics of DNA Topoisomerase II in Drosophila Chromosomes (1994)
Doctoral advisorDavid Agard & John Sedat
WebsiteOME
Research Profile

Education and career

Prof. Swedlow received a B.A. in Chemistry from Brandeis University in Waltham, Massachusetts, in 1982. He then earned a Ph.D. in Biophysics from UCSF in 1994, under the direction of Dr. David Agard and Dr. John Sedat. After a postdoctoral fellowship with Dr Tim Mitchison at UCSF and then Harvard Medical School, Dr Swedlow established his own laboratory in 1998 at the Wellcome Trust Biocentre, University of Dundee, as a Wellcome Trust Career Development Fellow. He was awarded a Wellcome Trust Senior Research Fellowship in 2002 and named Professor of Quantitative Cell Biology in 2007. From 2021-2024, he has a part-time secondment as a Program Director at Wellcome Leap, running the Delta Tissue Program. He was named a Fellow of the Royal Society of Edinburgh in 2012 and appointed an Honorary OBE in 2021.

Research

Prof. Swedlow's research[1] focuses on mechanisms and regulation of chromosome segregation during mitotic cell division[2][3][4][5][6][7][8] and the development of software tools for accessing, processing, sharing and publishing large scientific image datasets.[9][10][11][12][13][14][15][16][17][18] He leads OME, an international consortium that develops and releases open source software for biological imaging and Glencoe Software, which commercialises and customises OME technology for use in academic and biopharmaceutical research (e.g., Columbus from PerkinElmer, CellLibrarian from Yokogawa, and Amira from Thermo Fisher Scientific. He participates in Euro-BioImaging, Global BioImaging, and is co-Founder of BioImagingUK, a consortium of UK imaging scientists that develop, use, or administer imaging solutions for life sciences research. Using OME technology, he has collaborated with EMBL-EBI to develop the Image Data Resource, a public data resource for reference images from bioimaging.

Teaching

Prof. Swedlow has served as Faculty (since 1997) and Co-Director (2009 - 2014) of the Analytical & Quantitative Light Microscopy Course at the Marine Biological Laboratory in Woods Hole, Massachusetts, and participates as Faculty in the NCBS Bangalore Microscopy Course.

Family

Prof. Swedlow is married to Dr Melpomeni Platani, and has two children, Jan and Lena.

References
  1. Jason Swedlow publications indexed by Google Scholar
  2. Andrews, P. D.; Ovechkina, Y.; Morrice, N.; Wagenbach, M.; Duncan, K.; Wordeman, L.; Swedlow, J. R. (2004). "Aurora B regulates MCAK at the mitotic centromere". Developmental Cell. 6 (2): 253–268. doi:10.1016/s1534-5807(04)00025-5. PMID 14960279.
  3. Posch, M.; Khoudoli, G. A.; Swift, S.; King, E. M.; Deluca, J. G.; Swedlow, J. R. (2010). "Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis" (PDF). The Journal of Cell Biology. 191 (1): 61–74. doi:10.1083/jcb.200912046. PMC 2953433. PMID 20921135.
  4. Jaqaman, K.; King, E. M.; Amaro, A. C.; Winter, J. R.; Dorn, J. F.; Elliott, H. L.; McHedlishvili, N.; McClelland, S. E.; Porter, I. M.; Posch, M.; Toso, A.; Danuser, G.; McAinsh, A. D.; Meraldi, P.; Swedlow, J. R. (2010). "Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases". The Journal of Cell Biology. 188 (5): 665–679. doi:10.1083/jcb.200909005. PMC 2835940. PMID 20212316.
  5. Moser, S. C.; Bensaddek, D.; Ortmann, B.; Maure, J. F.; Mudie, S.; Blow, J. J.; Lamond, A. I.; Swedlow, J. R.; Rocha, S. (2013). "PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192". Developmental Cell. 26 (4): 381–392. doi:10.1016/j.devcel.2013.06.014. PMC 3757158. PMID 23932902.
  6. Porter, I. M.; Schleicher, K.; Porter, M.; Swedlow, J. R. (2013). "Bod1 regulates protein phosphatase 2A at mitotic kinetochores". Nature Communications. 4: 2677. Bibcode:2013NatCo...4.2677P. doi:10.1038/ncomms3677. PMC 3826647. PMID 24157919.
  7. Esmaeeli-Nieh, Sahar; Fenckova, Michaela; Porter, Iain M.; Motazacker, M. Mahdi; Nijhof, Bonnie; Castells-Nobau, Anna; Asztalos, Zoltan; Weißmann, Robert; Behjati, Farkhondeh; Tzschach, Andreas; Felbor, Ute; Scherthan, Harry; Sayfati, Seyed Morteza; Ropers, H. Hilger.; Kahrizi, Kimia; Najmabadi, Hossein; Swedlow, Jason R.; Schenck, Annette; Kuss, Andreas W. (2016). "BOD1 Is Required for Cognitive Function in Humans and Drosophila". PLOS Genetics. 12 (5): e1006022. doi:10.1371/journal.pgen.1006022. PMC 4864283. PMID 27166630.
  8. Zdańkowski, Piotr; Trusiak, Maciej; McGloin, David; Swedlow, Jason R. (2020). "Numerically Enhanced Stimulated Emission Depletion Microscopy with Adaptive Optics for Deep-Tissue Super-Resolved Imaging" (PDF). ACS Nano. 14 (1): 394–405. doi:10.1021/acsnano.9b05891. PMID 31841303. S2CID 209388232.
  9. Swedlow, J. R.; Goldberg, I.; Brauner, E.; Sorger, P. K. (2003). "Informatics and Quantitative Analysis in Biological Imaging". Science. 300 (5616): 100–102. Bibcode:2003Sci...300..100S. doi:10.1126/science.1082602. PMC 3522889. PMID 12677061.
  10. Goldberg, I. G.; Allan, C.; Burel, J. M.; Creager, D.; Falconi, A.; Hochheiser, H.; Johnston, J.; Mellen, J.; Sorger, P. K.; Swedlow, J. R. (2005). "The Open Microscopy Environment (OME) Data Model and XML file: Open tools for informatics and quantitative analysis in biological imaging". Genome Biology. 6 (5): R47. doi:10.1186/gb-2005-6-5-r47. PMC 1175959. PMID 15892875.
  11. Swedlow, J. R.; Goldberg, I. G.; Eliceiri, K. W.; Ome, C. (2009). "Bioimage Informatics for Experimental Biology*". Annual Review of Biophysics. 38: 327–346. doi:10.1146/annurev.biophys.050708.133641. PMC 3522875. PMID 19416072.
  12. Allan, C.; Burel, J. M.; Moore, J.; Blackburn, C.; Linkert, M.; Loynton, S.; MacDonald, D.; Moore, W. J.; Neves, C.; Patterson, A.; Porter, M.; Tarkowska, A.; Loranger, B.; Avondo, J.; Lagerstedt, I.; Lianas, L.; Leo, S.; Hands, K.; Hay, R. T.; Patwardhan, A.; Best, C.; Kleywegt, G. J.; Zanetti, G.; Swedlow, J. R. (2012). "OMERO: Flexible, model-driven data management for experimental biology". Nature Methods. 9 (3): 245–253. doi:10.1038/nmeth.1896. PMC 3437820. PMID 22373911.
  13. Burel, JM; Besson, S; Blackburn, C; Carroll, M; Ferguson, RK; Flynn, H; Gillen, K; Leigh, R; Li, S; Lindner, D; Linkert, M; Moore, WJ; Ramalingam, B; Rozbicki, E; Tarkowska, A; Walczysko, P; Allan, C; Moore, J; Swedlow, JR (2015). "Publishing and sharing multi-dimensional image data with OMERO". Mammalian Genome. 26 (9–10): 441–7. doi:10.1007/s00335-015-9587-6. PMC 4602067. PMID 26223880.
  14. Li, S; Besson, S; Blackburn, C; Carroll, M; Ferguson, RK; Flynn, H; Gillen, K; Leigh, R; Lindner, D; Linkert, M; Moore, WJ; Ramalingam, B; Rozbicki, E; Rustici, G; Tarkowska, A; Walczysko, P; Williams, E; Allan, C; Burel, JM; Moore, J; Swedlow, JR (2016). "Metadata management for high content screening in OMERO". Methods. 96: 27–32. doi:10.1016/j.ymeth.2015.10.006. PMC 4773399. PMID 26476368.
  15. Williams E, Moore J, Li SW, Rustici G, Tarkowska A, Chessel A, et al. (2017). "The Image Data Resource: A Bioimage Data Integration and Publication Platform". Nat Methods. 14 (8): 775–781. doi:10.1038/nmeth.4326. PMC 5536224. PMID 28775673.
  16. Ellenberg, Jan; Swedlow, Jason R.; Barlow, Mary; Cook, Charles E.; Sarkans, Ugis; Patwardhan, Ardan; Brazma, Alvis; Birney, Ewan (2018). "A call for public archives for biological image data". Nature Methods. 15 (11): 849–854. doi:10.1038/s41592-018-0195-8. PMC 6884425. PMID 30377375.
  17. Besson, Sébastien; Leigh, Roger; Linkert, Melissa; Allan, Chris; Burel, Jean-Marie; Carroll, Mark; Gault, David; Gozim, Riad; Li, Simon; Lindner, Dominik; Moore, Josh; Moore, Will; Walczysko, Petr; Wong, Frances; Swedlow, Jason R. (2019). "Bringing Open Data to Whole Slide Imaging". Digital Pathology. Lecture Notes in Computer Science. 11435: 3–10. doi:10.1007/978-3-030-23937-4_1. ISBN 978-3-030-23936-7. PMC 6774793. PMID 31579322.
  18. Moore, Josh; Allan, Chris; Besson, Sébastien; Burel, Jean-Marie; Diel, Erin; Gault, David; Kozlowski, Kevin; Lindner, Dominik; Linkert, Melissa; Manz, Trevor; Moore, Will; Pape, Constantin; Tischer, Christian; Swedlow, Jason R. (December 2021). "OME-NGFF: a next-generation file format for expanding bioimaging data-access strategies". Nature Methods. 18 (12): 1496–1498. doi:10.1038/s41592-021-01326-w.
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