Joan B. Broderick

Joan Blanchette Broderick is a professor of chemistry and biochemistry at Montana State University known for her work on bioinorganic chemistry, especially the chemistry of iron-sulfur interactions. She was elected a member of the National Academy of Sciences in 2022.[1]

Joan Blanchette Broderick
Alma materNorthwestern University
Scientific career
InstitutionsMontana State University
ThesisSpectroscopic and mechanistic studies of chlorocatechol dioxygenase, a non-heme iron dioxygenase with broad substrate tolerance (1992)

Education and career

Broderick has an undergraduate degree from Washington State University, and an M.S. and a PhD from Northwestern University. Following her Ph.D., she was a postdoc at Massachusetts Institute of Technology and then an assistant professor at Amherst College. She held a faculty position at Michigan State University before moving to Montana in 2005.[2]

She has been recognized as a Saltman Lecturer and Women in Science Distinguished Professor at Montana State University.[3] In 2019, Broderick received the Alfred Bader Award in Bioinorganic or Bioorganic Chemistry from the American Chemical Society.[4]

Research

She has contributed to bioinorganic chemistry often with a focus on iron-sulfur proteins, including the radical SAM enzymes.[5] Her research also includes investigations into hydrogenase where she defines the assembly of the enzymes into functional units.[6][7]

Selected publications
  • Mulder, David W.; Boyd, Eric S.; Sarma, Ranjana; Lange, Rachel K.; Endrizzi, James A.; Broderick, Joan B.; Peters, John W. (May 2010). "Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydAΔEFG". Nature. 465 (7295): 248–251. Bibcode:2010Natur.465..248M. doi:10.1038/nature08993. PMID 20418861. S2CID 1990191.
  • Peters, John W.; Schut, Gerrit J.; Boyd, Eric S.; Mulder, David W.; Shepard, Eric M.; Broderick, Joan B.; King, Paul W.; Adams, Michael W. W. (1 June 2015). "[FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1853 (6): 1350–1369. doi:10.1016/j.bbamcr.2014.11.021. ISSN 0167-4889. PMID 25461840.
  • Broderick, Joan B.; Duffus, Benjamin R.; Duschene, Kaitlin S.; Shepard, Eric M. (23 April 2014). "Radical S -Adenosylmethionine Enzymes". Chemical Reviews. 114 (8): 4229–4317. doi:10.1021/cr4004709. PMC 4002137. PMID 24476342.

References
  1. "2022 NAS Election".
  2. "People". Broderick Research Group. 2017-10-09. Retrieved 2021-10-07.
  3. "Joan Broderick - Chemistry and Biochemistry - Montana State University". www.chemistry.montana.edu.
  4. "2019 ACS National Award winners". Chemical & Engineering News. Retrieved 2019-01-22.
  5. Broderick, J. B.; Duffus, B. R.; Duschene, K. S.; Shepard, E. M., "Radical S-Adenosylmethionine Enzymes", Chemical Reviews 2014, volume 114, 4229-4317. 10.1021/cr4004709
  6. Shepard, Eric M.; McGlynn, Shawn E.; Bueling, Alexandra L.; Grady-Smith, Celestine S.; George, Simon J.; Winslow, Mark A.; Cramer, Stephen P.; Peters, John W.; Broderick, Joan B. (2010-06-08). "Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold". Proceedings of the National Academy of Sciences. 107 (23): 10448–10453. Bibcode:2010PNAS..10710448S. doi:10.1073/pnas.1001937107. ISSN 0027-8424. PMC 2890834. PMID 20498089.
  7. Peters, John W.; Broderick, Joan B. (2012-07-07). "Emerging Paradigms for Complex Iron-Sulfur Cofactor Assembly and Insertion". Annual Review of Biochemistry. 81 (1): 429–450. doi:10.1146/annurev-biochem-052610-094911. ISSN 0066-4154. PMID 22482905.
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