Johan Elf

Per Johan Sven Elf, (born May 8, 1975) is a Swedish biophysicist. As of 2013 he is professor of physical biology at Uppsala universitet, Department of Cell and Molecular Biology. He is a member of the board of Uppsala University.

Johan Elf
Johan Elf in 2017
Born
Per Johan Sven Elf

(1975-05-08) May 8, 1975
Motala, Sweden
Alma materUppsala University (PhD)
AwardsGustafsson Prize in 2010
Scientific career
FieldsBiophysics
InstitutionsUppsala University
ThesisIntracellular flow and fluctuations 2004
Doctoral advisorMåns Ehrenberg
Websiteelflab.icm.uu.se

He is a member of the Chemistry class at the Swedish Royal Academy of Sciences since 2016[1] and EMBO since 2022.

He founded the company Astrego in 2017[2] and Bifrost Biosystems in 2022.

Elf studies dynamic processes in bacterial cells using sensitive optical methods and quantitative models. His main contributions is within the following categories: Genetic encoding,[3] algorithms for spatially-dependent stochastic simulations,[4] methods for single molecule tracking in living cells,[5] mechanisms of molecular search kinetics [6][7][8] and antibiotic susceptibility testing.[9]

References
  1. "Kungl. Vetenskapsakademien". www.kva.se. Retrieved 28 September 2017.
  2. "Astrego Diagnostics - Develops the fastest antibiotic susceptibility test". Astrego Diagnostics. Retrieved 2021-06-12.
  3. Elf J, Nilsson D, Tenson T, Ehrenberg M (June 2003). "Selective charging of tRNA isoacceptors explains patterns of codon usage". Science. 300 (5626): 1718–22. Bibcode:2003Sci...300.1718E. doi:10.1126/science.1083811. PMID 12805541. S2CID 19695995.
  4. Elf J, Ehrenberg M (December 2004). "Spontaneous separation of bi-stable biochemical systems into spatial domains of opposite phases". Systems Biology. 1 (2): 230–6. doi:10.1049/sb:20045021. PMID 17051695.
  5. Balzarotti F, Eilers Y, Gwosch KC, Gynnå AH, Westphal V, Stefani FD, Elf J, Hell SW (February 2017). "Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes". Science. 355 (6325): 606–612. arXiv:1611.03401. Bibcode:2017Sci...355..606B. doi:10.1126/science.aak9913. PMID 28008086. S2CID 5418707.
  6. Elf J, Li GW, Xie XS (May 2007). "Probing transcription factor dynamics at the single-molecule level in a living cell". Science. 316 (5828): 1191–4. Bibcode:2007Sci...316.1191E. doi:10.1126/science.1141967. PMC 2853898. PMID 17525339.
  7. Hammar P, Leroy P, Mahmutovic A, Marklund EG, Berg OG, Elf J (June 2012). "The lac repressor displays facilitated diffusion in living cells". Science. 336 (6088): 1595–8. Bibcode:2012Sci...336.1595H. doi:10.1126/science.1221648. PMID 22723426. S2CID 21351861.
  8. Marklund, et al. (2020). "DNA surface exploration and operator bypassing during target search" (PDF). Nature. 583 (7818): 858–861. Bibcode:2020Natur.583..858M. doi:10.1038/s41586-020-2413-7. PMID 32581356. S2CID 220049852.
  9. Baltekin Ö, Boucharin A, Tano E, Andersson DI, Elf J (August 2017). "Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging". Proceedings of the National Academy of Sciences of the United States of America. 114 (34): 9170–9175. Bibcode:2017PNAS..114.9170B. doi:10.1073/pnas.1708558114. PMC 5576829. PMID 28790187.
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