John Marioni

John Marioni is the Head of Research at the European Bioinformatics Institute and holds an appointment at the Wellcome Sanger Institute and the Cancer Research UK Cambridge Institute in Cambridge University.[2] He is a computational biologist known for his research on statistical and computational methods for the analysis of genomics data, in particular single-cell biology and evolutionary genomics. He co-chairs the Human Cell Atlas Analysis Working Group.[3]

John Marioni
Alma materUniversity of Cambridge
Scientific career
FieldsComputational biology
Human Genetics
single-cell biology
InstitutionsUniversity of Chicago
University of Cambridge
ThesisStatistical methods for arrayCGH and copy number variation experiments[1] (2007)
Doctoral advisorSimon Tavaré

Research and career

Marioni has conducted influential studies in whole-tissue and single-cell transcriptomics.[4] He received his PhD from the University of Cambridge in Applied Mathematics in 2008. He conducted postdoctoral studies in the University of Chicago under Matthew Stephens.[5][6]

Marioni is known for "pioneering the statistical analysis of gene expression patterns in individual cells, which has led to a radical paradigm shift in the field of transcriptomics."[7]

Awards and honours

Select publications
  • R Argelaguet, SJ Clark, H Mohammed, et al., JC Marioni, W Reik. Multi-omics Profiling of Mouse Gastrulation at Single-cell Resolution. Nature. doi:10.1038/s41586-019-1825-8
  • L Haghverdi, ATL Lun, MD Morgan, JC Marioni. Batch Effects in Single-cell RNA-sequencing Data are Corrected by Matching Mutual Nearest Neighbors. Nature Biotechnology. doi:10.1038/nbt.4091
  • B Pijuan-Sala, JA Griffiths, C Guibentif, et al., JC Marioni, B Göttgens. A Single-cell Molecular Map of Mouse Gastrulation and Early Organogenesis. Nature. doi:10.1038/s41586-019-0933-9
  • T Lohoff, S Ghazanfar, A Missarova, N Koulena, N Pierson, JA Griffiths, ES Bardot, CL Eng, RCV Tyser, R Argelaguet, C Guibentif, S Srinivas, J Briscoe, BD Simons, AK Hadjantonakis, B Göttgens, W Reik, J Nichols, L Cai, JC Marioni. Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis. Nature Biotechnology. doi:10.1038/s41587-021-01006-2
  • R Argelaguet, ASE Cuomo, O Stegle, JC Marioni. Computational principles and challenges in single-cell data integration. Nature Biotechnology. doi:10.1038/s41587-021-00895-7.

References
  1. "John Marioni". Mathematics Genealogy Project. Retrieved 2022-01-05.
  2. "Marioni Group". Cancer Research UK Cambridge Institute. Retrieved 2022-01-05.
  3. "Human Cell Atlas Working Groups". www.humancellatlas.org. Retrieved 2022-01-05.
  4. "John Marioni publications indexed by Google Scholar". scholar.google.com. Retrieved 2022-01-05.
  5. EMBL-EBI | John Marioni
  6. Cell Symposia | Speaker | John Marioni, EMBL-European Bioinformatics Institute, UK
  7. "2021 United Kingdom Award Finalist". blavatnikawards.org. Retrieved 2022-01-05.
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