Imidacloprid/permethrin/pyriproxyfen

Imidacloprid/permethrin/pyriproxyfen, sold under the trade name K9 Advantix II, is a combination insecticide product for dogs, used for the treatment and prevention of an array of common external parasites. It is effective against fleas, ticks, chewing lice and mosquitoes.[1] The active ingredients are imidacloprid, permethrin, and pyriproxyfen. This product is toxic to cats,[2] and it is not recommended to use it on dogs which share an environment with cats.[1] The product is applied onto the skin; administration of the product into the mouth can cause adverse effects.[3]

"Advantix" redirects here. For Kodak film format, see Advanced Photo System.
Imidacloprid/permethrin/pyriproxyfen
Combination of
ImidaclopridInsecticide
PermethrinPyrethroid insecticide
PyriproxyfenInsecticide
Clinical data
Trade namesK9 Advantix II

The product is designed for topical use and should be applied directly to the skin, ideally at the base of the neck or between the shoulder blades where the dog cannot easily lick it off. The application should ensure that the product reaches the skin and not just the hair, for optimal effectiveness.[4] After application, the ingredients spread across the skin and coat, providing comprehensive protection.

References
  1. Koch SN, Torres SM, Plumb DC (1 May 2012). Canine and Feline Dermatology Drug Handbook. John Wiley & Sons. pp. 336–337. ISBN 978-1-4051-9896-7.
  2. Bill RL (2017). "Current (2016) flea and tick products used in small animals (major U.S. brands)". Clinical Pharmacology and Therapeutics for Veterinary Technicians (4th ed.). St Louis, Missouri: Elsevier Inc. p. 278. ISBN 978-0-323-08679-0.
  3. Wanamaker BP, Massey KL (2015). "Imidacloprid, Imidacloprid with Permethrin, and Imidaclopride with Moxidectin". Applied pharmacology for veterinary technicians (5th ed.). St Louis, Missouri: Elsevier Inc. p. 226. ISBN 978-0-323-18662-9.
  4. "Permethrin Cream for Scabies". ClickPharmacy. Retrieved 2023-08-25.


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