KATNB1

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.[5][6]

KATNB1
Identifiers
AliasesKATNB1, KAT, LIS6, katanin regulatory subunit B1
External IDsOMIM: 602703 MGI: 1921437 HomoloGene: 4302 GeneCards: KATNB1
Orthologs
SpeciesHumanMouse
Entrez

10300

74187

Ensembl

ENSG00000140854

ENSMUSG00000031787

UniProt

Q9BVA0

Q8BG40

RefSeq (mRNA)

NM_005886

NM_028805

RefSeq (protein)

NP_005877

NP_083081

Location (UCSC)Chr 16: 57.74 – 57.76 MbChr 8: 95.81 – 95.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.[6] KATNB1 is associated with microlissencephaly.

References

  1. GRCh38: Ensembl release 89: ENSG00000140854 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031787 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (May 1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719. S2CID 13583382.
  6. "Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.