KDM3A

KDM3A
Identifiers
Aliases	KDM3A, JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA, lysine demethylase 3A
External IDs	OMIM: 611512 MGI: 98847 HomoloGene: 10196 GeneCards: KDM3A
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	86,492,716 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	71,609,974 bp[2]
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; sperm; ; sural nerve; ; skin of abdomen; ; right lung; ; ganglionic eminence; ; gastric mucosa; ; minor salivary gland; ; human penis;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; left lung lobe; ; ganglionic eminence; ; medial ganglionic eminence; ; thymus; ; mirror; ; cumulus cell; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; DNA-binding transcription factor activity; dioxygenase activity; metal ion binding; androgen receptor binding; oxidoreductase activity; histone demethylase activity; transcription cis-regulatory region binding; chromatin DNA binding; histone H3-methyl-lysine-9 demethylase activity; protein binding; RNA polymerase II core promoter sequence-specific DNA binding;
Cellular component	cytoplasm; membrane; nucleoplasm; nucleus; chromatin;
Biological process	androgen receptor signaling pathway; cell differentiation; regulation of transcription, DNA-templated; histone H3-K9 dimethylation; regulation of stem cell differentiation; regulation of stem cell population maintenance; transcription, DNA-templated; positive regulation of transcription, DNA-templated; spermatogenesis; hormone-mediated signaling pathway; negative regulation of histone H3-K9 methylation; regulation of gene expression; formaldehyde biosynthetic process; spermatid nucleus elongation; positive regulation of transcription by RNA polymerase II; histone H3-K9 demethylation; cellular response to leukemia inhibitory factor; chromatin organization; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55818
	104263
	ENSG00000115548
	ENSMUSG00000053470
	Q9Y4C1
	Q6PCM1
	NM_001146688; NM_018433
	NM_001038695; NM_173001; NM_001362200; NM_001362201
	NP_001140160; NP_060903
	NP_001033784; NP_766589; NP_001349129; NP_001349130
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene.[5]

Function

This gene encodes a zinc finger protein that contains a jumonji C (JmjC) domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. KDM3A catalyzes the demethylation of H3K9me1 and H3K9me2 residues. Its function is dependent on the presence of cofactors Fe(II) and α-Ketoglutarate.[6]

References

GRCh38: Ensembl release 89: ENSG00000115548 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000053470 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Lysine demethylase 3A".
Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y (May 2006). "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor". Cell. 125 (3): 483–495. doi:10.1016/j.cell.2006.03.027. PMID 16603237. S2CID 6643329.

KDM3A

Function

References

Further reading