Kinesin-associated protein 3

KIFAP3
Identifiers
Aliases	KIFAP3, FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1, kinesin associated protein 3
External IDs	OMIM: 601836 MGI: 107566 HomoloGene: 7799 GeneCards: KIFAP3
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	170,085,208 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	163,744,678 bp[2]
RNA expression pattern
	Top expressed in
	pons; ; orbitofrontal cortex; ; Brodmann area 46; ; frontal pole; ; postcentral gyrus; ; prefrontal cortex; ; ganglionic eminence; ; sperm; ; dorsolateral prefrontal cortex; ; spinal ganglia;
	Top expressed in
	barrel cortex; ; facial motor nucleus; ; nucleus accumbens; ; prefrontal cortex; ; subiculum; ; pontine nuclei; ; temporal lobe; ; medial dorsal nucleus; ; anterior horn of spinal cord; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; kinesin binding; intraciliary transport particle B binding; protein phosphatase binding;
Cellular component	intraciliary transport particle; ciliary basal body; cytosol; centrosome; Golgi apparatus; kinesin complex; microtubule cytoskeleton; kinesin II complex; photoreceptor connecting cilium; condensed nuclear chromosome; ciliary tip; spindle microtubule; endoplasmic reticulum; periciliary membrane compartment; axoneme; cilium;
Biological process	protein localization; plus-end-directed vesicle transport along microtubule; antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of apoptotic process; microtubule-based movement; positive regulation of calcium-dependent cell-cell adhesion; microtubule-based process; signal transduction; negative regulation of cell population proliferation; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; intraciliary transport involved in cilium assembly; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	22920
	16579
	ENSG00000075945
	ENSMUSG00000026585
	Q92845
	P70188
NM_001204514; NM_001204516; NM_001204517; NM_014970; NM_001375830;
	NM_001375831
	NM_010629; NM_001305643
NP_001191443; NP_001191445; NP_001191446; NP_055785; NP_001362759;
	NP_001362760
	NP_001292572; NP_034759
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-associated protein 3 (KAP3) is a protein that in humans is encoded by the KIFAP3 gene.[5][6] It is a non-motor, accessory subunit which co-oligomerizes with the motor subunits KIF3A and KIF3B or KIF3C, to form heterotrimeric kinesin-2 motor proteins. Kinesin-2 KAP subunits were initially characterized in echinoderms and mice.[7][8]

Function

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 Armadillo repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein.[6] It has also been proposed to act as a clamp, stabilizing the C-terminal half [9] of the otherwise unstable stalk coiled-coil.

Interactions

KIFAP3 has been shown to interact with APC,[10] SMC3[11] and RAP1GDS1.[5]

References

GRCh38: Ensembl release 89: ENSG00000075945 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026585 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y (Dec 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J Biol Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. PMID 8900189.
"Entrez Gene: KIFAP3 kinesin-associated protein 3".
Wedaman KP, Meyer DW, Rashid DJ, Cole DG, Scholey JM (February 1996). "Sequence and submolecular localization of the 115-kD accessory subunit of the heterotrimeric kinesin-II (KRP85/95) complex". J. Cell Biol. 132 (3): 371–80. doi:10.1083/jcb.132.3.371. PMC 2120715. PMID 8636215.
Yamazaki H, Nakata T, Okada Y, Hirokawa N (August 1996). "Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8443–8. Bibcode:1996PNAS...93.8443Y. doi:10.1073/pnas.93.16.8443. PMC 38690. PMID 8710890.
Ahmed Z, Mazumdar S, Ray K (February 2020). "Kinesin associated protein, DmKAP, binding harnesses the C-terminal ends of the Drosophila kinesin-2 stalk heterodimer". Biochem Biophys Res Commun. 522 (2): 506–511. doi:10.1016/j.bbrc.2019.11.111. PMC 8407544. PMID 31784087.
Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T (April 2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily". Nat. Cell Biol. 4 (4): 323–7. doi:10.1038/ncb779. PMID 11912492. S2CID 10745049.
Shimizu K, Shirataki H, Honda T, Minami S, Takai Y (March 1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". J. Biol. Chem. 273 (12): 6591–4. doi:10.1074/jbc.273.12.6591. PMID 9506951.

Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
Shimizu K, Shirataki H, Honda T, et al. (1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". J. Biol. Chem. 273 (12): 6591–4. doi:10.1074/jbc.273.12.6591. PMID 9506951.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Khanna H, Hurd TW, Lillo C, et al. (2005). "RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins". J. Biol. Chem. 280 (39): 33580–7. doi:10.1074/jbc.M505827200. PMC 1249479. PMID 16043481.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Brown CL, Maier KC, Stauber T, et al. (2006). "Kinesin-2 is a motor for late endosomes and lysosomes". Traffic. 6 (12): 1114–24. doi:10.1111/j.1600-0854.2005.00347.x. PMID 16262723.
Haraguchi K, Hayashi T, Jimbo T, et al. (2006). "Role of the kinesin-2 family protein, KIF3, during mitosis". J. Biol. Chem. 281 (7): 4094–9. doi:10.1074/jbc.M507028200. PMID 16298999.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Kuraguchi M, Wang XP, Bronson RT, et al. (2006). "Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus". PLOS Genet. 2 (9): e146. doi:10.1371/journal.pgen.0020146. PMC 1564426. PMID 17002498.
Stauber T, Simpson JC, Pepperkok R, Vernos I (2007). "A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex". Curr. Biol. 16 (22): 2245–51. doi:10.1016/j.cub.2006.09.060. PMID 17113389. S2CID 9739953.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075945 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026585 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8900189-5] Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y (Dec 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J Biol Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. PMID 8900189.

[entrez-6] "Entrez Gene: KIFAP3 kinesin-associated protein 3".

[pmid8636215-7] Wedaman KP, Meyer DW, Rashid DJ, Cole DG, Scholey JM (February 1996). "Sequence and submolecular localization of the 115-kD accessory subunit of the heterotrimeric kinesin-II (KRP85/95) complex". J. Cell Biol. 132 (3): 371–80. doi:10.1083/jcb.132.3.371. PMC 2120715. PMID 8636215.

[pmid8710890-8] Yamazaki H, Nakata T, Okada Y, Hirokawa N (August 1996). "Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8443–8. Bibcode:1996PNAS...93.8443Y. doi:10.1073/pnas.93.16.8443. PMC 38690. PMID 8710890.

[pmid_=_31784087-9] Ahmed Z, Mazumdar S, Ray K (February 2020). "Kinesin associated protein, DmKAP, binding harnesses the C-terminal ends of the Drosophila kinesin-2 stalk heterodimer". Biochem Biophys Res Commun. 522 (2): 506–511. doi:10.1016/j.bbrc.2019.11.111. PMC 8407544. PMID 31784087.

[pmid11912492-10] Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T (April 2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily". Nat. Cell Biol. 4 (4): 323–7. doi:10.1038/ncb779. PMID 11912492. S2CID 10745049.

[pmid9506951-11] Shimizu K, Shirataki H, Honda T, Minami S, Takai Y (March 1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". J. Biol. Chem. 273 (12): 6591–4. doi:10.1074/jbc.273.12.6591. PMID 9506951.

Kinesin-associated protein 3

Function

Interactions

References

Further reading