KIRREL2

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene.[5][6][7] It is primarily expressed in β cells of the pancreatic islets.[5]

KIRREL2
Identifiers
AliasesKIRREL2, FILTRIN, NEPH3, NLG1, kin of IRRE like 2 (Drosophila), kirre like nephrin family adhesion molecule 2
External IDsOMIM: 607762 MGI: 2442334 HomoloGene: 35249 GeneCards: KIRREL2
Orthologs
SpeciesHumanMouse
Entrez

84063

243911

Ensembl

ENSG00000126259

ENSMUSG00000036915

UniProt

Q6UWL6

Q7TSU7

RefSeq (mRNA)

NM_032123
NM_199179
NM_199180
NM_001329530
NM_001363667

NM_172898

RefSeq (protein)

NP_001316459
NP_115499
NP_954648
NP_954649
NP_001350596

NP_766486

Location (UCSC)Chr 19: 35.86 – 35.87 MbChr 7: 30.15 – 30.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3). NEPH proteins bind the

References

  1. GRCh38: Ensembl release 89: ENSG00000126259 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036915 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sun C, Kilburn D, Lukashin A, Crowell T, Gardner H, Brundiers R, Diefenbach B, Carulli JP (Jul 2003). "Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets". Genomics. 82 (2): 130–42. doi:10.1016/S0888-7543(03)00110-1. PMID 12837264.
  6. Ihalmo P, Palmen T, Ahola H, Valtonen E, Holthofer H (Dec 2002). "Filtrin is a novel member of nephrin-like proteins". Biochem Biophys Res Commun. 300 (2): 364–70. doi:10.1016/S0006-291X(02)02854-1. PMID 12504092.
  7. "Entrez Gene: KIRREL2 kin of IRRE like 2 (Drosophila)".

Further reading


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