KLC2

Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene.[5][6]

KLC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLC2, kinesin light chain 2
External IDsOMIM: 611729 MGI: 107953 HomoloGene: 22468 GeneCards: KLC2
Orthologs
SpeciesHumanMouse
Entrez

64837

16594

Ensembl

ENSG00000174996

ENSMUSG00000024862

UniProt

Q9H0B6

O88448

RefSeq (mRNA)

NM_001134774
NM_001134775
NM_001134776
NM_022822
NM_001318734

NM_008451
NM_001369360
NM_001369361
NM_001369362

RefSeq (protein)

NP_001128246
NP_001128247
NP_001128248
NP_001305663
NP_073733

n/a

Location (UCSC)Chr 11: 66.26 – 66.27 MbChr 19: 5.16 – 5.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

KLC2 has been shown to interact with MAPK8IP3[7] and KIF5B.[5][8]

Model organisms

Model organisms have been used in the study of KLC2 function. A conditional knockout mouse line called Klc2tm1e(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[9] Male and female animals underwent a standardized phenotypic screen[10] to determine the effects of deletion.[11][12][13][14] Additional screens performed: - In-depth immunological phenotyping[15]

References

  1. GRCh38: Ensembl release 89: ENSG00000174996 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024862 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. PMID 9624122.
  6. "Entrez Gene: KLC2 kinesin light chain 2".
  7. Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Nov 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729. S2CID 247102.
  8. Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125. PMID 10491391.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. "International Mouse Phenotyping Consortium".
  11. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  12. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  13. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  14. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  15. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

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