Importin subunit alpha-5

Importin subunit alpha-5 is a protein that in humans is encoded by the KPNA1 gene.[5]

KPNA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKPNA1, IPOA5, NPI-1, RCH2, SRP1, Importin, Karyopherin alpha 1, karyopherin subunit alpha 1
External IDsOMIM: 600686 MGI: 103560 HomoloGene: 55642 GeneCards: KPNA1
Orthologs
SpeciesHumanMouse
Entrez

3836

16646

Ensembl

ENSG00000114030

ENSMUSG00000022905

UniProt

P52294

Q60960

RefSeq (mRNA)

NM_002264

NM_008465

RefSeq (protein)

NP_002255

NP_032491

Location (UCSC)Chr 3: 122.42 – 122.51 MbChr 16: 35.8 – 35.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

Importin subunit alpha-5 has been shown to interact with KPNB1[6][7] and UBR5.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000114030 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022905 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cortes P, Ye ZS, Baltimore D (Sep 1994). "RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1". Proc Natl Acad Sci U S A. 91 (16): 7633–7. Bibcode:1994PNAS...91.7633C. doi:10.1073/pnas.91.16.7633. PMC 44456. PMID 8052633.
  6. Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Mol. Cell. Biol. UNITED STATES. 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. ISSN 0270-7306. PMC 84838. PMID 10523667.
  7. Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import". J. Mol. Biol. ENGLAND. 266 (4): 722–32. doi:10.1006/jmbi.1996.0801. ISSN 0022-2836. PMID 9102465.
  8. Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. United States. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095.

Further reading

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