Importin subunit alpha-4

Importin subunit alpha-4 also known as karyopherin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene.[5][6]

KPNA3
Identifiers
AliasesKPNA3, IPOA4, SRP1, SRP1gamma, SRP4, hSRP1, karyopherin subunit alpha 3
External IDsOMIM: 601892 MGI: 1100863 HomoloGene: 20520 GeneCards: KPNA3
Orthologs
SpeciesHumanMouse
Entrez

3839

16648

Ensembl

ENSG00000102753

ENSMUSG00000021929

UniProt

O00505

O35344

RefSeq (mRNA)

NM_002267

NM_008466

RefSeq (protein)

NP_002258

NP_032492

Location (UCSC)Chr 13: 49.7 – 49.79 MbChr 14: 61.6 – 61.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60–100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system.[7]

Interactions

KPNA3 has been shown to interact with KPNB1.[6][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000102753 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021929 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Takeda S, Fujiwara T, Shimizu F, Kawai A, Shinomiya K, Okuno S, Ozaki K, Katagiri T, Shimada Y, Nagata M, Watanabe T, Takaichi A, Kuga Y, Suzuki M, Hishigaki H, Takahashi E, Shin S, Nakamura Y, Hirai Y (June 1997). "Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1". Cytogenet Cell Genet. 76 (1–2): 87–93. doi:10.1159/000134521. PMID 9154134.
  6. Nachury MV, Ryder UW, Lamond AI, Weis K (February 1998). "Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor". Proc Natl Acad Sci U S A. 95 (2): 582–7. Bibcode:1998PNAS...95..582N. doi:10.1073/pnas.95.2.582. PMC 18463. PMID 9435235.
  7. "Entrez Gene: KPNA3 karyopherin alpha 3 (importin alpha 4)".
  8. Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (November 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import" (PDF). Mol. Cell. Biol. UNITED STATES. 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. hdl:11858/00-001M-0000-0015-3C39-0. ISSN 0270-7306. PMC 84838. PMID 10523667.

Further reading


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