Karmella Haynes

Karmella Ann Haynes is a biomedical engineer and associate professor at the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University.[1][2] She researches how chromatin is used to control cell development in biological tissue.

Karmella Haynes
Born
St. Louis, Missouri, U.S.
Alma materWashington University in St. Louis Ph.D (2006)
Florida A&M University B.S. (1999)
Known forChromatin, Synthetic Biology, Epigenetics, Cancer
Awards
Scientific career
Institutions
Thesis (2006)
Doctoral advisorSarah Elgin
Websitekhayneslab.wordpress.com

Early life and education

Haynes was born and raised in St. Louis.[3] She received her B.S. in biology from Florida A&M University (where she had received a full scholarship) in 1999 .[4][5] While at Florida A&M, she participated in a summer research program working with Mary-Lou Pardue at Massachusetts Institute of Technology as part of the MIT Summer Research Program.[6][7][8]

Haynes did her graduate work in the lab of Sarah Elgin at Washington University in St. Louis.[4][6] She received her Ph.D. in molecular genetics in 2006 for her work studying chromatin dynamics and epigenetics in Drosophila.[9][10][11][12]

As a Howard Hughes Medical Institute fellow, she completed her first postdoctoral fellowship in teaching at Davidson College under the guidance of Laurie Heyer and Malcolm Campbell.[4][5] During her time as a fellow, Haynes redesigned the undergraduate bioinformatics teaching course and won publication of the year from the Journal of Biological Engineering for her article Engineering bacteria to solve the Burnt Pancake Problem.[13][14][15][16][17] She was introduced to synthetic biology and became a member of Davidson's 2006 iGEM team.[18]

Haynes went on to complete a second postdoctoral fellowship in Pamela Silver's lab at Harvard Medical School where she leveraged her experience with chromatin dynamics and synthetic biology to create artificial transcription factors which activated genes based on histone methylation.[6][19][12]

Academic career and research

After her postdoctoral fellowships in 2011, Haynes started her lab in the School of Biological and Health Systems Engineering at Arizona State University (ASU).[20][21] There, her lab focused on creating epigenetic machinery that can regulate DNA.[22] The proteins themselves are fusion transcription factors, which can target particular genes.[23] She hopes to increase the use of technology in therapeutics, working on tissue regeneration and customizable protein-based drugs.[24] In 2015 she was awarded a K01 grant to study the use of modular peptide motifs to build synthetic chromatin proteins that activate dormant therapeutic genes.[25] During her time at ASU, she was the faculty advisor for the ASU iGEM team.[26]

In 2018, Haynes moved to the W.H. Coulter Biomedical Engineering Department at Georgia Tech/Emory University.[27][5] During her time here, she founded the AfroBiotech conference and the Cold Spring Harbor Summer Course on Synthetic Biology.[28][29] She was on the responsible conduct committee for IGEM in 2018 and 2019.[30][31]

Public engagement

Haynes has appeared on PBS, talking about biotechnology and disease.[32] Alongside research, Haynes is an accomplished artist.[33][34] In 2011, she painted her poster presentation for the Fifth International Meeting of Synthetic Biology (SB5.0) conference.[35] Her artwork is still on the walls at Harvard University.[6] She is a member of the Building with Biology public engagement project.[36] She has been featured twice on Science Friday.[37]

Awards and honors
  • 2017 Outstanding Assistant Professor, School of Biological and Health Systems Engineering
  • 2013 Scientists to Watch, The Scientist Magazine
  • 2012 Fellow, Synthetic Biology Leadership Excellence Accelerator Program (SynBio LEAP)
  • 2012 Gold Medal and Human Practices Award, International Genetically Engineered Machines Competition (iGEM)
  • 2010 Gold Medal, International Genetically Engineered Machines Competition (iGEM)
  • 2010 Sustainability Grant, Harvard University
  • 2009 Ruth L. Kirschstein National Research Service Award, National Institutes of Health
  • 2008 Outstanding Publication of 2008, Journal of Biological Engineering (JBE)[4]

Professional memberships
  • Director of Engineering Biology Research Consortium (ERBC) [38][39]
  • SynBioLEAP alum [38]
  • iGEM Advisor and Judge Emeritus[40]
  • AIChE[41]

Notable papers

As of August 16, 2020 based on Google Scholar citations:

  • cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four [42] (111 citations)
  • Preparing synthetic biology for the world [43] (97 citations)
  • Element 1360 and RNAi components contribute to HP1-dependent silencing of a pericentric reporter [44] (94 citations)
  • The impact of chromatin dynamics on Cas9-mediated genome editing in human cells [10] (82 citations)
  • Engineering bacteria to solve the Burnt Pancake Problem [17] (73 citations)
  • Synthetic reversal of epigenetic silencing[45] (51 citations)
  • Eukaryotic systems broaden the scope of synthetic biology[46] (51 citations)

References
  1. "Faculty | Coulter Department of Biomedical Engineering at Georgia Tech and Emory University". bme.gatech.edu. Retrieved 2020-08-16.
  2. "Karmella A. Haynes, PhD". winshipcancer.emory.edu. Retrieved 2020-08-16.
  3. "About". Karmella Haynes | Artist. 2015-04-05. Retrieved 2018-05-10.
  4. "2017 General Purpose". www.ncbi.nlm.nih.gov. Retrieved 2018-05-10.
  5. "The Cell Conductor". Grow by Ginkgo. 2020-06-23. Retrieved 2020-07-12.
  6. "Karmella Haynes: Turning the Dials". The Scientist. Retrieved 2018-05-10.
  7. "MIT Summer Research Program – General (MSRP) | Office of Graduate Education". Retrieved 2020-07-12.
  8. "Karmella Haynes: Synthetic Biologist, Artist, Advocate, and Ultimate Puzzle Solver". Benchling. 2019-02-12. Retrieved 2020-07-13.
  9. Haynes, Karmella A.; Caudy, Amy A.; Collins, Lynne; Elgin, Sarah C.R. (2006-11-21). "Element 1360 and RNAi Components Contribute to HP1-Dependent Silencing of a Pericentric Reporter". Current Biology. 16 (22): 2222–2227. doi:10.1016/j.cub.2006.09.035. ISSN 0960-9822. PMC 1712676. PMID 17113386.
  10. Daer, René M.; Cutts, Josh P.; Brafman, David A.; Haynes, Karmella A. (2017-03-17). "The Impact of Chromatin Dynamics on Cas9-Mediated Genome Editing in Human Cells". ACS Synthetic Biology. 6 (3): 428–438. doi:10.1021/acssynbio.5b00299. ISSN 2161-5063. PMC 5357160. PMID 27783893.
  11. Nyer, David B.; Daer, Rene M.; Vargas, Daniel; Hom, Caroline; Haynes, Karmella A. (2017-01-09). "Regulation of cancer epigenomes with a histone-binding synthetic transcription factor". npj Genomic Medicine. 2. doi:10.1038/s41525-016-0002-3. ISSN 2056-7944. PMC 5600530. PMID 28919981.
  12. Haynes, Karmella A.; Silver, Pamela A. (2011-08-05). "Synthetic Reversal of Epigenetic Silencing". The Journal of Biological Chemistry. 286 (31): 27176–27182. doi:10.1074/jbc.C111.229567. ISSN 0021-9258. PMC 3149311. PMID 21669865.
  13. "Time to Teach" (PDF). HHMI. Retrieved 2018-05-10.
  14. "Living computers solve complex math puzzle". NBC News. 2008-06-02. Retrieved 2018-05-10.
  15. "Environment". The Telegraph. 2016-03-30. ISSN 0307-1235. Archived from the original on 2016-04-01. Retrieved 2018-05-10.
  16. "Calculating Bacteria: Real Computer Bugs?". NPR.org. Retrieved 2018-05-10.
  17. Haynes, Karmella A.; Broderick, Marian L.; Brown, Adam D.; Butner, Trevor L.; Dickson, James O.; Harden, W. Lance; Heard, Lane H.; Jessen, Eric L.; Malloy, Kelly J. (2008). "Engineering bacteria to solve the Burnt Pancake Problem". Journal of Biological Engineering. 2 (1): 8. doi:10.1186/1754-1611-2-8. ISSN 1754-1611. PMC 2427008. PMID 18492232.
  18. "Davidson 2006 - 2006.igem.org". 2006.igem.org. Retrieved 2020-07-12.
  19. Haynes, Karmella A.; Ceroni, Francesca; Flicker, Daniel; Younger, Andrew; Silver, Pamela A. (2012). "A Sensitive Switch for Visualizing Natural Gene Silencing in Single Cells". ACS Synthetic Biology. 1 (3): 99–106. doi:10.1021/sb3000035. PMC 3331714. PMID 22530199.
  20. "Engineers from Day One". Issuu. Retrieved 2018-05-10.
  21. "Karmella Haynes". asu.pure.elsevier.com. Archived from the original on 2018-05-11. Retrieved 2018-05-10.
  22. "Karmella Haynes-Farrell | EBRC". www.ebrc.org. Archived from the original on 2018-05-11. Retrieved 2018-05-10.
  23. "BME Lecture Series: Karmella Haynes, Arizona State University | The Henry Samueli School of Engineering at UC Irvine". engineering.uci.edu. Retrieved 2018-05-10.
  24. "314: Dr. Karmella Haynes: Expressing Her Creativity Making Epigenetic Machinery and Designing Biological Devices - People Behind the Science Podcast". www.peoplebehindthescience.com. 2015-10-12. Retrieved 2018-05-10.
  25. Karmella, Haynes. "Synthetic chromatin for cancer research". Grantome.
  26. "Team:Arizona State/Team - 2017.igem.org". 2017.igem.org. Retrieved 2018-05-10.
  27. "People". Haynes Lab | Emory. 2015-12-26. Retrieved 2020-07-13.
  28. "AfroBiotech Conference 2019". www.aiche.org. 2019-03-06. Retrieved 2020-07-13.
  29. "Synthetic Biology | CSHL". meetings.cshl.edu. Retrieved 2020-07-13.
  30. "Competition/Responsible Conduct - 2018.igem.org". 2018.igem.org. Retrieved 2020-07-13.
  31. "Competition/Rules of Conduct/Responsible Conduct - 2019.igem.org". 2019.igem.org. Retrieved 2020-07-13.
  32. "Career Profile: Synthetic Biologist Karmella Haynes". PBS LearningMedia. Retrieved 2018-05-10.
  33. "Combining art and science: Karmella Haynes interview". betterposters.blogspot.co.uk. 2011-09-22. Retrieved 2018-05-10.
  34. "Karmella Haynes - Artist". The Scientist. Retrieved 2018-05-10.
  35. "More art & science – hand painted poster at Synthetic Biology #synbio5 – by Karmella Haynes". Jonathan Eisen's Lab. 2011-06-16. Retrieved 2018-05-10.
  36. "Meet Our Scientists". www.buildingwithbiology.org. Retrieved 2018-05-10.
  37. "Karmella Haynes - Science Friday". Science Friday. Retrieved 2018-05-10.
  38. "Karmella Haynes". SB7.0. Retrieved 2020-07-13.
  39. "Our Members | EBRC". Retrieved 2020-07-13.
  40. "Karmella Haynes, PH.D. - Assistant Professor at Emory University". The Ella Project. June 2018. Retrieved 2020-07-13.
  41. "Karmella A. Haynes". www.aiche.org. 2017-07-19. Retrieved 2020-07-13.
  42. Sun, Fang-Lin; Haynes, Karmella; Simpson, Cory L.; Lee, Susan D.; Collins, Lynne; Wuller, Jo; Eissenberg, Joel C.; Elgin, S. C. R. (September 2004). "cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four". Molecular and Cellular Biology. 24 (18): 8210–8220. doi:10.1128/MCB.24.18.8210-8220.2004. ISSN 0270-7306. PMC 515050. PMID 15340080.
  43. Moe-Behrens, Gerd H. G.; Davis, Rene; Haynes, Karmella A. (2013-01-25). "Preparing synthetic biology for the world". Frontiers in Microbiology. 4: 5. doi:10.3389/fmicb.2013.00005. ISSN 1664-302X. PMC 3554958. PMID 23355834.
  44. Haynes, Karmella A.; Caudy, Amy A.; Collins, Lynne; Elgin, Sarah C.R. (2006-11-21). "Element 1360 and RNAi Components Contribute to HP1-Dependent Silencing of a Pericentric Reporter". Current Biology. 16 (22): 2222–2227. doi:10.1016/j.cub.2006.09.035. ISSN 0960-9822. PMC 1712676. PMID 17113386.
  45. Haynes, Karmella A.; Silver, Pamela A. (2011-08-05). "Synthetic Reversal of Epigenetic Silencing". Journal of Biological Chemistry. 286 (31): 27176–27182. doi:10.1074/jbc.C111.229567. ISSN 0021-9258. PMC 3149311. PMID 21669865. S2CID 11842108.
  46. Haynes, Karmella A.; Silver, Pamela A. (2009-11-30). "Eukaryotic systems broaden the scope of synthetic biology". Journal of Cell Biology. 187 (5): 589–596. doi:10.1083/jcb.200908138. ISSN 0021-9525. PMC 2806586. PMID 19948487.
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