Katja Schenke-Layland

Katja Schenke-Layland (born Eisenach, Germany, March 21, 1977) is the Professor of Medical Technologies and Regenerative Medicine, Institute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine at the University of Tübingen.[1] She is the Director of the NMI Natural and Medical Sciences Institute at the University Tübingen in Reutlingen,[2] Study Dean of Medical Technologies at the University of Tübingen, and Founding Director of the Institute of Biomedical Engineering at the Medical Faculty of the University Tübingen. She is also the Founding Director of the 3R Center for In Vitro Models and Alternatives to Animal Testing Tübingen.

Katja Schenke-Layland
Born
Katja Schenke

(1977-03-21) 21 March 1977
Eisenach, Germany
NationalityGerman, American
Alma mater
Occupations
  • Professor
  • Institute Director
  • CEO
Websiteschenke-layland-lab.com

Early research

Katja Schenke-Layland began her doctoral work in the area of heart valve tissue engineering and non-invasive imaging at the University of Jena, Germany. Her specific interest was the effect of cryopreservation, decellularization/recellularization and biomechanical forces on heart valve extracellular matrix (ECM) structures and cells.[3][4][5] She helped develop the use of multiphoton laser-based confocal microscopy and second harmonic generation as non-invasive tissue imaging tools.[6] For her post-doctoral work, she focused on cardiac stem cell biology and biomaterials. Here, her seminal work was to be the first scientist to demonstrate that induced pluripotent stem cells (iPSCs) differentiate towards the cardiovascular and hematopoietic lineages, showing that beating cardiomyocytes could be derived from iPSCs.[7][8] She then returned to Germany to join the Fraunhofer IGB in Stuttgart, Germany as a group leader, which was then followed by her appointment as Professor in the Medical Faculty of the University of Tübingen, and promotion to Department Head and later Director of the Fraunhofer IGB. She remained focused on cardiovascular development[9][10] and biomaterials,[11] and moved into the areas of in vitro test systems[12][13] and Raman microspectroscopy,[14][15] with a focus on ECM proteins.

Awards
  • Best Young Researcher Award/ Family Klee Prize, German Society for Biomedical Engineering[16]
  • Young Investigator Morphological Sciences Award, American Association of Anatomists[17]
  • Academia.net top female scientists in Germany[18]
  • Tissue Engineering and Regenerative Medicine International Society (TERMIS)-EU Young Investigator Award[19]
  • CyberOne Business Plan Competition Finalist[20]
  • RPB Harold F. Spalter International Scholar Award[21]
  • Germany’s Top 100 Innovators[22]
  • German Stem Cell Network GSCN 2021 Hilde Mangold Award [23]

Research focus

Currently, her research lab at the University Tübingen focuses on the translation of human development into clinically relevant biomaterials and regenerative therapies, and the development of diagnostic tools to assess (stem) cell states, discover therapeutic candidates and diagnose diseases.[24] She leverages her appointments to bridge the gaps between science and industry to drive viable health care solutions, particularly at the NMI where they focus on supporting local SMEs[25]

Editorial work

Katja Schenke-Layland is currently the Co-Editor-In-Chief of Tissue Engineering Part B (Mary Ann Liebert) and Executive Editor of Advanced Drug Delivery Reviews[26] (Elsevier), as well as on the editorial boards of Matrix Biology (journal)[27] (Elsevier), Current Opinion in Biomedical Engineering (Elsevier), Journal of 3D Printing in Medicine (Future Medicine) and Scientific Reports (Nature Research). She is a fellow/ board member of the German National Academy of Science and Engineering,[28] German Central Ethics Committee for Stem Cell Research,[29] International and German Societies of Matrix Biology and the European Alliance for Medical and Biological Engineering and Science.

References
  1. "FIT - Portfolio". fit.uni-tuebingen.de.
  2. "Prof. Dr. Katja Schenke-Layland - NMI.de". www.nmi.de.
  3. Schenke-Layland, Katja; Madershahian, Navid; Riemann, Iris; Starcher, Barry; Halbhuber, Karl-Jürgen; König, Karsten; Stock, Ulrich A. (March 2006). "Impact of Cryopreservation on Extracellular Matrix Structures of Heart Valve Leaflets". The Annals of Thoracic Surgery. 81 (3): 918–926. doi:10.1016/j.athoracsur.2005.09.016. PMID 16488695.
  4. Schenke-Layland, K.; Vasilevski, O.; Opitz, F.; König, K.; Riemann, I.; Halbhuber, K.J.; Wahlers, Th.; Stock, U.A. (September 2003). "Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves". Journal of Structural Biology. 143 (3): 201–208. doi:10.1016/j.jsb.2003.08.002. PMID 14572475.
  5. Schenke-Layland, K; Opitz, F; Gross, M; Döring, C; Halbhuber, KJ; Schirrmeister, F; Wahlers, T; Stock, UA (1 December 2003). "Complete dynamic repopulation of decellularized heart valves by application of defined physical signals—an in vitro study". Cardiovascular Research. 60 (3): 497–509. doi:10.1016/j.cardiores.2003.09.002. PMID 14659795.
  6. König, K.; Schenke-Layland, K.; Riemann, I.; Stock, U.A. (February 2005). "Multiphoton autofluorescence imaging of intratissue elastic fibers". Biomaterials. 26 (5): 495–500. doi:10.1016/j.biomaterials.2004.02.059. PMID 15276357.
  7. Schenke-Layland, Katja; Rhodes, Katrin E.; Angelis, Ekaterini; Butylkova, Yekaterina; Heydarkhan-Hagvall, Sepideh; Gekas, Christos; Zhang, Rui; Goldhaber, Joshua I.; Mikkola, Hanna K.; Plath, Kathrin; MacLellan, W. Robb (June 2008). "Reprogrammed Mouse Fibroblasts Differentiate into Cells of the Cardiovascular and Hematopoietic Lineages". Stem Cells. 26 (6): 1537–1546. doi:10.1634/stemcells.2008-0033. PMC 2873147. PMID 18450826.
  8. Schenke-Layland, Katja; MacLellan, W. Robb (13 October 2009). "Induced Pluripotent Stem Cells: It's Like Déjà Vu All Over Again". Circulation. 120 (15): 1462–1464. doi:10.1161/CIRCULATIONAHA.109.898544. PMC 2898560. PMID 19786628.
  9. Votteler, Miriam; Berrio, Daniel A. Carvajal; Horke, Alexander; Sabatier, Laetitia; Reinhardt, Dieter P.; Nsair, Ali; Aikawa, Elena; Schenke-Layland, Katja (1 June 2013). "Elastogenesis at the onset of human cardiac valve development". Development. 140 (11): 2345–2353. doi:10.1242/dev.093500. PMC 3912871. PMID 23637335.
  10. Monaghan, Michael G.; Linneweh, Miriam; Liebscher, Simone; Van Handel, Ben; Layland, Shannon L.; Schenke-Layland, Katja (1 January 2015). "A spatiotemporal observation of EndMT and mesenchymal cell colonization at the onset of human cardiac valve development". Development. 143 (3): 473–482. doi:10.1242/dev.133843. PMC 4760315. PMID 26674310.
  11. Hinderer, Svenja; Seifert, Jan; Votteler, Miriam; Shen, Nian; Rheinlaender, Johannes; Schäffer, Tilman E.; Schenke-Layland, Katja (February 2014). "Engineering of a bio-functionalized hybrid off-the-shelf heart valve". Biomaterials. 35 (7): 2130–2139. doi:10.1016/j.biomaterials.2013.10.080. PMID 24333025.
  12. Brauchle, Eva; Johannsen, Hannah; Nolan, Samantha; Thude, Sibylle; Schenke-Layland, Katja (October 2013). "Design and analysis of a squamous cell carcinoma in vitro model system". Biomaterials. 34 (30): 7401–7407. doi:10.1016/j.biomaterials.2013.06.016. PMID 23827189.
  13. Zbinden, Aline; Marzi, Julia; Schlünder, Katharina; Probst, Christopher; Urbanczyk, Max; Black, Scott; Brauchle, Eva M.; Layland, Shannon L.; Kraushaar, Udo; Duffy, Garry; Schenke-Layland, Katja; Loskill, Peter (January 2020). "Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model". Matrix Biology. 85–86: 205–220. doi:10.1016/j.matbio.2019.06.008. PMID 31238092.
  14. Brauchle, Eva; Kasper, Jana; Daum, Ruben; Schierbaum, Nicolas; Falch, Claudius; Kirschniak, Andreas; Schäffer, Tilman E.; Schenke-Layland, Katja (August 2018). "Biomechanical and biomolecular characterization of extracellular matrix structures in human colon carcinomas". Matrix Biology. 68–69: 180–193. doi:10.1016/j.matbio.2018.03.016. PMID 29605717.
  15. Marzi, Julia; Biermann, Anna C.; Brauchle, Eva M.; Brockbank, Kelvin G. M.; Stock, Ulrich A.; Schenke-Layland, Katja (5 February 2019). "Marker-Independent In Situ Quantitative Assessment of Residual Cryoprotectants in Cardiac Tissues". Analytical Chemistry. 91 (3): 2266–2272. doi:10.1021/acs.analchem.8b04861. PMID 30601652.
  16. "Klee-Preis".
  17. "Early-Career Investigator Awards".
  18. "Prof. Dr. Katja Schenke-Layland - AcademiaNet".
  19. "Chapters - Europe - Committees - Awards Committee | TERMIS".
  20. "Home". cyberone.de.
  21. "Research to Prevent Blindness (RPB) Harold F. Spalter International Research Scholar Award for Katja Schenke-Layland – Tissue Engineering of the Lacrimal Gland - Fraunhofer IGB".
  22. "Best Innovators: Germany's Quiet Visionaries". www.handelsblatt.com.
  23. "German Stem Cell Network Awards". www.gscn.org.
  24. "Schenke-Layland Lab". www.schenke-layland-lab.com.
  25. "Home - NMI.de". www.nmi.de.
  26. "Katja Schenke-Layland". www.journals.elsevier.com.
  27. "Katja Schenke-Layland, MSc, PhD". www.journals.elsevier.com.
  28. "Katja Schenke-Layland NMI Naturwissenschaftliches und Medizinisches Institut".
  29. "RKI - Mitglieder". www.rki.de.
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