Kelch-like protein 12

Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene.[5][6]

KLHL12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLHL12, C3IP1, DKIR, hDKIR, kelch like family member 12
External IDsOMIM: 614522 MGI: 2385619 HomoloGene: 23317 GeneCards: KLHL12
Orthologs
SpeciesHumanMouse
Entrez

59349

240756

Ensembl

ENSG00000117153

ENSMUSG00000026455

UniProt

Q53G59

Q8BZM0

RefSeq (mRNA)

NM_001303051
NM_001303109
NM_021633

NM_153128
NM_001311136

RefSeq (protein)

NP_001289980
NP_001290038
NP_067646

NP_001298065
NP_694768

Location (UCSC)Chr 1: 202.89 – 202.93 MbChr 1: 134.38 – 134.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

KLHL12 has been shown to interact with RIT1[7] and CUL3.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000117153 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026455 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. "Entrez Gene: KLHL12 kelch-like 12 (Drosophila)".
  7. Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (April 2008). "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase". The Journal of Biological Chemistry. 283 (17): 11083–96. doi:10.1074/jbc.M708473200. PMC 2431063. PMID 18303015.

Further reading

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