Korkut Uygun

M. Korkut Uygun is a Turkish chemical engineer and a medical researcher.

Korkut Uygun
BornJan, 1975
Bonn, Germany
NationalityTurkish
Alma materBoğaziçi University, Wayne State University
AwardsNIH Pathway to Independence Award, 2008; Massachusetts General Hospital Junior Faculty Award, 2009
Scientific career
FieldsTransplantation, Systems Biology, Biomedical Engineering
InstitutionsHarvard Medical School, Massachusetts General Hospital
Doctoral advisorYinlun Huang

Career

Uygun received his BSc and MSc from Boğaziçi University in Istanbul, Turkey, with Dr. Ugur Akman as his advisor on both his MSc and BSc theses.[1] He received Ph.D. in chemical engineering from Wayne State University in 2004.[2] After working for 2 years as a post-doctoral researcher in the research laboratory of the department where he received his Ph.D., in 2006 he became a research associate in the "Center for Engineering in Medicine" of the Massachusetts General Hospital,[3] where he became the leader of the Organ Engineering Group. In 2008, he was promoted to instructor in surgery (Bioengineering) at Harvard Medical School.[4] In 2011 he was promoted to Assistant Professor in Surgery at Harvard Medical School, before being promoted to Associate Professor a few years later.[5]

Work

A major research objective of Uygun is to enhance utilization of discarded donor organs in order to either increase the supply of transplantable organs, utilize untransplantable organs as cell sources for cell transplantation or bioartificial organ substitutes, such as bioartificial livers, and if the organ proves completely unresuscitatable, utilize them as biocompatible scaffolds for tissue engineering. In 2010, a team led by Uygun in the Center for Engineering in Medicine at Massachusetts General Hospital developed a technique that someday may allow growth of transplantable replacement livers.[6] Uygun's technique developed functional, transplantable rat liver grafts.[7] The study was published in Nature Medicine.[8] Uygun highlighted the significance of his work by saying, "As far as we know, a transplantable liver graft has never been constructed in a laboratory setting before".[9] A novel technique was also used to "reintroduce hepatocytes, the cells that carry out most of the liver’’s primary functions, into the decellularized matrix".[10] The study was reported as "the first steps in growing working livers".[11] It is also the basis of a patent application.

Research Awards

In 2008, Uygun was awarded a Career Award by NIDDK at NIH "Computer-Aided Development of a Liver Organ Culture System".[4]

In 2009, Uygun was awarded by the National Science Foundation for a research project, "Liver Reengineering".[12] which has funded the studies for whole organ decellularization and recellularization.

Uygun is also a Co-investigator and collaborator on several projects with Martin Yarmush and Mehmet Toner

Personal life

Uygun is married to Başak E. Saygılı, who is also a medical researcher and faculty at Harvard Medical School and Center for Engineering in Medicine; the couple has a daughter called Elif Naz.[13]

References
  1. Ugur Akman's CV, Turkey: Boğaziçi University, Jan 2000, retrieved 13 May 2011
  2. Lab News of 2004, U.S.A.: Wayne State University, 24 June 2004, retrieved 15 June 2010
  3. Lab News of 2006, U.S.A.: Wayne State University, 7 July 2006, retrieved 15 June 2010
  4. Lab News of 2008, U.S.A.: Wayne State University, 28 April 2008, retrieved 15 June 2010
  5. CEM News, U.S.A.: Center for Engineering in Medicine, 2 March 2011, retrieved 13 May 2011
  6. Mass. General researchers develop functional, transplantable rat liver grafts, Massachusetts General Hospital - News Releases, 13 June 2010, retrieved 15 June 2010
  7. Mass. General researchers develop functional, transplantable rat liver grafts, e! Science News, 13 June 2010, retrieved 15 June 2010
  8. Basak E Uygun, Alejandro Soto-Gutierrez, Hiroshi Yagi, Maria-Louisa Izamis, Maria A Guzzardi, Carley Shulman, Jack Milwid, Naoya Kobayashi, Arno Tilles, Francois Berthiaume, Martin Hertl, Yaakov Nahmias, Martin L Yarmush, Korkut Uygun. "Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix". Nature Medicine, 2010; doi:10.1038/nm.2170
  9. Functional, Transplantable Rat Liver Grafts: Discarded Livers Have Potential to Be Reengineered Into Usable Replacement Organs, ScienceDaily, 15 June 2010, retrieved 15 June 2010
  10. Advance made towards development of transplantable replacement livers, Infoway, 14 June 2010, archived from the original on 21 July 2011, retrieved 15 June 2010
  11. "Scientists take first steps in growing working livers". BBC News. 13 June 2010. Retrieved 15 June 2010.
  12. Lab News of 2009, U.S.A.: Wayne State University, 1 September 2009, retrieved 15 June 2010
  13. Lab News of 2010, U.S.A.: Wayne State University, 2 April 2010, retrieved 15 June 2010
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