Krzysztof Palczewski

Krzysztof Palczewski (born 1957) is a Polish-American biochemist working at the University of California, Irvine.

Krzysztof Palczewski
Born1957
Syców, Poland
Alma materUniversity of Wrocław, Wrocław University of Technology
Known forRhodopsin
AwardsHumboldt Research Award
Prize of the Foundation for Polish Science (2012)[1]

ARVO Friedenwald award (2014) [2]
Beckman-Argyros award in Vision Research (2015)
Polish Academy of Arts and Sciences (2015, foreign member)
Marie Curie Medal (2017)
RRF Paul Kayser International Award in Retina Research (2018)

Goodman and Gilman Award in Receptor Pharmacology (2022)[3]
Scientific career
FieldsBiochemistry
InstitutionsCase Western Reserve University; University of California, Irvine
Doctoral advisorMarian Kochman
Website

He is a Member of the National Academy of Sciences and the National Academy of Medicine.

In 2012 he was awarded Prize of the Foundation for Polish Science, the most prestigious scientific award for Polish scientists, for characterizing crystal structures of native and activated G protein-coupled receptor, rhodopsin, involved in eyesight.[1]

His MS and PhD, are from the University of Wroclaw and Technical University of Wroclaw, respectively (Poland). His early posts were at the University of Florida and the Oregon Health Sciences University. Dr. Palczewski completed much of his pivotal research at the University of Washington. In 2005 he moved to become the Chair and John H. Hord professor of Pharmacology at Case Western Reserve University. In 2018 he joined University of California, Irvine, where he is a Distinguished Professor and is leading the Center for Translational Vision Research.[4]


Research interests

Palczewski's research interest lie in mapping the Visual Transduction System. His work with determining the crystal structure of rhodopsin has given new insight into the function of G protein receptors. Furthermore, his work on visual cycle has led to revolutionary advances in understanding hereditary blindness, leading to implementation of novel pharmacological treatments that can slow retinal degeneration in adults.[5][6] His team's efforts indicate that repetitive 2-photon imaging of the human eye can safely reveal the visual system's sub-cellular architecture and that humans can detect infrared light due to simultaneous 2-photon absorption.[7][8] Recently, Palczewski and co-workers applied a new generation of CRISPR technology, base editing as a treatment for inherited retinal diseases.[9]

References

Notes
  1. "Prof. Krzysztof Palczewski - FNP Prize 2012 laureate".
  2. Polans, Arthur S. (2014). "Introducing Krzysztof Palczewski, the 2014 Recipient of the Friedenwald Award". Investigative Ophthalmology & Visual Science. 55 (10): 6649–50. doi:10.1167/iovs.14-14843. PMID 25338685.
  3. "News Detail".
  4. "UCI Center for Translational Vision Research".
  5. Jacobson, S. G.; Aleman, T. S.; Cideciyan, A. V.; Sumaroka, A.; Schwartz, S. B.; Windsor, E. A. M.; Traboulsi, E. I.; Heon, E.; Pittler, S. J.; Milam, A. H.; Maguire, A. M.; Palczewski, K.; Stone, E. M.; Bennett, J. (2005). "Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success". Proceedings of the National Academy of Sciences. 102 (17): 6177–6182. Bibcode:2005PNAS..102.6177J. doi:10.1073/pnas.0500646102. PMC 1087926. PMID 15837919.
  6. Maeda, Akiko (2006). "Aberrant Metabolites in Mouse Models of Congenital Blinding Diseases: Formation and Storage of Retinyl Esters†". Biochemistry. 45 (13): 4210–4219. doi:10.1021/bi052382x. PMC 1560103. PMID 16566595.
  7. Palczewska, Grazyna; Dong, Zhiqian; Golczak, Marcin; Hunter, Jennifer J.; Williams, David R.; Alexander, Nathan S.; Palczewski, Krzysztof (2014). "Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye". Nature Medicine. 20 (7): 785–789. doi:10.1038/nm.3590. PMC 4087080. PMID 24952647.
  8. Palczewska, Grazyna; Vinberg, Frans; Stremplewski, Patrycjusz; Bircher, Martin P.; Salom, David; Komar, Katarzyna; Zhang, Jianye; Cascella, Michele; Wojtkowski, Maciej; Kefalov, Vladimir J.; Palczewski, Krzysztof (2014). "Human infrared vision is triggered by two-photon chromophore isomerization". Proceedings of the National Academy of Sciences. 111 (50): E5445–E5454. Bibcode:2014PNAS..111E5445P. doi:10.1073/pnas.1410162111. PMC 4273384. PMID 25453064.
  9. Choi, Elliot H.; Suh, Susie; Foik, Andrzej T.; Leinonen, Henri; Newby, Gregory A.; Gao, Xin D.; Banskota, Samagya; Hoang, Thanh; Du, Samuel W.; Dong, Zhiqian; Raguram, Aditya (2022-04-05). "In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration". Nature Communications. 13 (1): 1830. Bibcode:2022NatCo..13.1830C. doi:10.1038/s41467-022-29490-3. ISSN 2041-1723. PMC 8983734. PMID 35383196.

Bibliography
  • Vertebrate Phototransduction and the Visual Cycle, Krzysztof Palczewski, Academic Press (2000), ISBN 0-12-182217-6
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