KTN1

Kinectin is a protein that in humans is encoded by the KTN1 gene.[3][4]

KTN1
Identifiers
AliasesKTN1, CG1, KNT, MU-RMS-40.19, kinectin 1
External IDsOMIM: 600381 HomoloGene: 135663 GeneCards: KTN1
Orthologs
SpeciesHumanMouse
Entrez

3895

n/a

Ensembl

ENSG00000126777

n/a

UniProt

Q86UP2

n/a

RefSeq (mRNA)

NM_001079521
NM_001079522
NM_001271014
NM_004986
NM_182926

n/a

RefSeq (protein)

NP_001072989
NP_001072990
NP_001257943
NP_004977

n/a

Location (UCSC)Chr 14: 55.56 – 55.7 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

Various cellular organelles and vesicles are transported along the microtubules in the cytoplasm. Likewise, membrane recycling of the endoplasmic reticulum (ER), Golgi assembly at the microtubule organizing center, and alignment of lysosomes along microtubules are all related processes. The transport of organelles requires a special class of microtubule-associated proteins (MAPs). One of these is the molecular motor kinesin (see MIM 148760 and MIM 600025), an ATPase that moves vesicles unidirectionally toward the plus end of the microtubule. Another such MAP is kinectin, a large integral ER membrane protein. Antibodies directed against kinectin have been shown to inhibit its binding to kinesin.[supplied by OMIM][4]

Interactions

KTN1 has been shown to interact with EEF1D,[5] RhoG[6][7] and RHOA.[6][7][8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000126777 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Rao PN, Yu H, Hodge R, Pettenati MJ, Sheetz MP (1997). "Assignment of the human kinectin gene (KTN1), encoding a kinesin-binding protein, to chromosome 14 band q22.1 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 196–7. doi:10.1159/000134719. PMID 9605849.
  4. "Entrez Gene: KTN1 kinectin 1 (kinesin receptor)".
  5. Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". J. Biol. Chem. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.
  6. Neudauer CL, Joberty G, Macara IG (Jan 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
  7. Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P (Dec 2001). "Kinectin is a key effector of RhoG microtubule-dependent cellular activity". Mol. Cell. Biol. 21 (23): 8022–34. doi:10.1128/MCB.21.23.8022-8034.2001. PMC 99969. PMID 11689693.
  8. Riento K, Guasch RM, Garg R, Jin B, Ridley AJ (Jun 2003). "RhoE binds to ROCK I and inhibits downstream signaling". Mol. Cell. Biol. 23 (12): 4219–29. doi:10.1128/MCB.23.12.4219-4229.2003. PMC 156133. PMID 12773565.
  9. Hotta K, Tanaka K, Mino A, Kohno H, Takai Y (Aug 1996). "Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor". Biochem. Biophys. Res. Commun. 225 (1): 69–74. doi:10.1006/bbrc.1996.1132. PMID 8769096.

Further reading


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