Kypros Nicolaides

Kyprianos "Kypros" Nicolaides FRCOG (born 9 April 1953) is a Greek Cypriot physician of British citizenship, Professor of Fetal Medicine at King's College Hospital, London. He is one of the pioneers of fetal medicine and his discoveries have revolutionised the field.[1] He was elected to the US National Academy of Medicine in 2020 for 'improving the care of pregnant women worldwide with pioneering rigorous and creative approaches, and making seminal contributions to prenatal diagnosis and every major obstetrical disorder'.[2] This is considered to be one of the highest honours in the fields of health and medicine and recognises individuals who have demonstrated outstanding professional achievement and commitment to service.[3]

Kypros Nicolaides
Nicolaides in 2011
Born (1953-04-09) 9 April 1953
Paphos, Cyprus
NationalityCypriot
CitizenshipBritish
Alma materKing's College London

Early life and education

Nicolaides was born in 1953 in Paphos, Cyprus, and attended The English School in Nicosia. He studied Biochemistry and Physiology at King's College London and Medicine at King's College School of Medicine and Dentistry in London, graduating in 1978. Soon after graduation, in 1980, he joined the Department of Obstetrics and Gynaecology, doing research with Professor Stuart Campbell and Professor Charles Rodeck as his first assistant, working mainly on fetoscopic techniques and procedures.[4] His manual dexterity at procedures and the Rodeck-Nicolaides team soon produced important papers on the use of fetoscopy in the management of a wide range of conditions such as Rhesus iso-immunization, fetal hydrops and intrauterine growth restriction, and procedures such as blood and tissue sampling in the diagnosis of single gene defects.[4]

Professional career

In 1986 Nicolaides became Director of the Harris Birthright Research Centre for Fetal Medicine, the first Fetal Medicine Unit in the United Kingdom, opened in 1984 by Diana, Princess of Wales. His programme of research and teaching made King's College Hospital the largest and most renowned centre for fetal medicine in the world.[4]

He has held the position of Professor of Fetal Medicine at King's College London since 1992.[5] He has been a member of several study groups of the Royal College of Obstetricians and Gynaecologists, the Chairman of the Educational Committee of the World Association of Perinatal Medicine and the Chairman of the Scientific Committee of the International Society of Ultrasound in Obstetrics and Gynecology.

He is also the Founder and Chairman of the UK Charity, the Fetal Medicine Foundation, which he set up in 1995.[6] The main source of income of the Charity is a private clinic, and the Fetal Medicine Foundation has donated more than £45 million to finance the training of doctors from around the world and to carry out major multi-centre research studies in fetal medicine.[6] The Fetal Medicine Foundation also organises the yearly World Congress in Fetal Medicine, which is attended by more than 2,000 participants and has implemented a series of internet-based educational courses for doctors and patients which are available free of charge.[7]

Nicolaides has authored over 1,500 peer-reviewed journal articles and more than 30 books and monographs. He has an H-index of 185, which is the highest of any Obstetrician & Gynaecologist in the world, and has had his research cited over 130,000 times.[8] He has supervised 55 doctors in obtaining PhD and MD qualifications and has provided training in Fetal Medicine to over 700 doctors from 50 countries.

Nicolaides has developed methods of (i) screening for premature birth (which is the main cause of perinatal morbidity and mortality) by measurement of cervical length and prevention through the use of vaginal progesterone,[9] (ii) screening for pre-eclampsia (which is one of the main causes of maternal mortality) by measurement of blood flow to the uterus by Doppler and measurement of blood pressure and the hormone placental growth factor and prevention through the use of aspirin,[10] (iii) methods of early screening for chromosomal abnormalities through the measurement of nuchal translucency,[11][12] and spina bifida through the ‘lemon and banana’ signs,[13] and (iv) methods of fetal therapy including fetal blood transfusions for red cell isoimmunized pregnancies,[14][15] thoraco-amniotic shunting for fetal pleural effusions,[16] endoscopic laser surgery for identical twin pregnancies with severe twin-to-twin transfusion syndrome in collaboration with Professor Yves Ville[17] and endoscopic placement of a balloon in the fetal trachea for the treatment of severe diaphragmatic hernia in collaboration with Professors Jan Deprest and Eduard Gratacos.[18] He has recently proposed a new model of pregnancy care - "Turning the Pyramid of Prenatal Care".[19] This aims to assess the risk for most of the relevant pregnancy complications affecting mother and unborn child during a hospital visit at 11–13 weeks of gestation and, on the basis of such risks, provide personalised care to reduce an adverse outcome.[20]

Awards and recognitions
  • Ian Donald Gold Medal for Highest Contribution in Ultrasound, International Society of Ultrasound in Obstetrics and Gynecology, 1999[4]
  • Erich Saling Award for Highest Scientific Contribution in Perinatal Medicine, World Association of Perinatal Medicine, 2001[21]
  • Excellence in Letters, Culture and Science, Government of Cyprus, 2004
  • Honorary Fellowship of The American Institute of Ultrasound in Medicine, USA, 2004
  • Membership of the International Academy of Perinatal Medicine, Barcelona, Spain, 2005[22]
  • Honorary Doctorate in Medicine, University of Athens, Greece, 2005
  • Honorary Doctorate in Medicine, Medical University of Warsaw, Poland, 2009
  • Honorary Doctorate in Medicine, University of Bucharest, Romania, 2009
  • Honorary Doctorate in Medicine, University of Jinan, China, 2010
  • Spinoza Chair, University of Amsterdam, the Netherlands, 2010
  • Honorary Doctorate in Medicine, Palacky University of Olomouc, Czech Republic, 2011
  • Honorary Professorship in Medicine, University of Ioannina, Greece, 2012
  • Honorary Doctorate in Medicine, European University of Cyprus, Cyprus, 2013
  • European Maternity Prize for distinction in professional career and dedication to the field of Perinatal Medicine, European Association of Perinatal Medicine, 2014[23]
  • Eardley Holland Gold Medal for outstanding contribution to the science, practice and teaching of Obstetrics & Gynaecology, Royal College of Obstetricians and Gynaecologists, 2015[24]
  • Honorary Doctorate in Medicine, University of Thessaly, Greece, 2016
  • Honorary Doctorate in Medicine, Aristotelion University of Thessaloniki, Greece, 2017
  • Honorary Doctorate in Medicine, Medical University of Pleven, Bulgaria, 2017
  • Honorary Doctorate in Medicine, University of Cyprus, Cyprus, 2017
  • Naguib Pasha Mahfouz Award, Cairo University, Egypt, 2018[25]
  • Honorary Doctorate in Medicine, University of Leuven, Belgium, 2019[26]
  • Honorary Doctorate in Medicine, University of Buenos Aires, Argentina, 2019
  • Honorary Fellowship of The Hong Kong College of Obstetricians and Gynaecologists, Hong Kong, 2020[27]
  • Member of the National Academy of Medicine, US, 2020[3]
  • Golden Cross of the Order of the Phoenix of the Hellenic Republic, Greece, 2022[28]

Television

The BBC television programme Life Before Birth is mainly about his work.[29]

Nicolaides also stars in the first episode of Netflix's docuseries The Surgeon's Cut, which was released in December 2020.[30] This episode follows Nicolaides at King's College Hospital in London where his ground-breaking work in endoscopic laser surgery is used to treat twin-to-twin transfusion syndrome, a life-threatening prenatal condition.[30]

References
  1. "The Fetal Medicine Foundation Belgium - Biography: Professor Kypros Nicolaides". www.fmfb.be. Retrieved 10 September 2017.
  2. "King's College Hospital - News". www.kch.nhs.uk. Archived from the original on 25 December 2021. Retrieved 20 November 2020.
  3. "National Academy of Medicine Elects 100 New Members". 19 October 2020.
  4. Kratochwil, A. (12 January 2000). "Presentations of the 1999 Ian Donald Gold Medals". Ultrasound in Obstetrics & Gynecology. 16 (1): 106–107. doi:10.1046/j.1469-0705.2000.00176.x. PMID 11084981.
  5. "Kypros Nicolaides - Research Portal, King's College, London". kclpure.kcl.ac.uk. Retrieved 10 September 2017.
  6. Foundation, The Fetal Medicine. "The Fetal Medicine Foundation". fetalmedicine.org.
  7. "FMF World Congress | Courses & Congress | Welcome to the Fetal Medicine Foundation". fetalmedicine.org.
  8. "Kypros Nicolaides - H-Index, Webometrics". webometrics.info. Retrieved 21 November 2020.
  9. Fonseca, E. B.; Celik, E.; Parra, M.; Singh, M.; Nicolaides, K. H.; Fetal Medicine Foundation Second Trimester Screening Group (2007). "Progesterone and the Risk of Preterm Birth among Women with a Short Cervix". The New England Journal of Medicine. 357 (5): 462–469. doi:10.1056/NEJMoa067815. PMID 17671254.
  10. Rolnik, D. L.; Wright, D.; Poon, L. C.; O'Gorman, N.; Syngelaki, A.; De Paco Matallana, C.; Akolekar, R.; Cicero, S.; Janga, D.; Singh, M.; Molina, F. S.; Persico, N.; Jani, J. C.; Plasencia, W.; Papaioannou, G.; Tenenbaum-Gavish, K.; Meiri, H.; Gizurarson, S.; MacLagan, K.; Nicolaides, K. H. (2017). "Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia". The New England Journal of Medicine. 377 (7): 613–622. doi:10.1056/nejmoa1704559. PMID 28657417. S2CID 1605902.
  11. Nicolaides, K. H.; Azar, G.; Byrne, D.; Mansur, C.; Marks, K. (1992). "Fetal nuchal translucency: Ultrasound screening for chromosomal defects in first trimester of pregnancy". BMJ (Clinical Research Ed.). 304 (6831): 867–869. doi:10.1136/bmj.304.6831.867. PMC 1882788. PMID 1392745.
  12. Snijders, RJM; Noble, P.; Sebire, N.; Souka, A.; Nicolaides, KH (1998). "UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10–14 weeks of gestation". The Lancet. 352 (9125): 343–346. doi:10.1016/S0140-6736(97)11280-6. PMID 9717920. S2CID 19797494.
  13. Nicolaides, K.H.; Gabbe, S.G.; Campbell, S.; Guidetti, R. (1986). "Ultrasound Screening for Spina Bifida: Cranial and Cerebellar Signs". The Lancet. 328 (8498): 72–74. doi:10.1016/S0140-6736(86)91610-7. PMID 2425202. S2CID 31571221.
  14. Nicolaides, K. H.; Soothill, P. W.; Rodeck, C. H.; Clewell, W. (12 January 1986). "Rh disease: intravascular fetal blood transfusion by cordocentesis". Fetal Therapy. 1 (4): 185–192. doi:10.1159/000262267. PMID 3136620.
  15. Nicolaides, K.H.; Clewell, W.H.; Mibashan, R.S.; Soothill, P.W.; Rodeck, C.H.; Campbell, S. (1988). "Fetal Haemoglobin Measurement in the Assessment of Red Cell Isoimmunisation". The Lancet. 331 (8594): 1073–1075. doi:10.1016/S0140-6736(88)91896-X. PMID 2452938. S2CID 13275361.
  16. Nicolaides, K. H.; Azar, G. B. (12 January 1990). "Thoraco-amniotic shunting". Fetal Diagnosis and Therapy. 5 (3–4): 153–164. doi:10.1159/000263586. PMID 2130840.
  17. Ville, Y.; Hyett, J.; Hecher, K.; Nicolaides, K. (1995). "Preliminary Experience with Endoscopic Laser Surgery for Severe Twin–Twin Transfusion Syndrome". The New England Journal of Medicine. 332 (4): 224–227. doi:10.1056/NEJM199501263320404. PMID 7808488.
  18. Deprest, J.; Gratacos, E.; Nicolaides, K. H.; FETO Task Group (2004). "Fetoscopic tracheal occlusion (FETO) for severe congenital diaphragmatic hernia: Evolution of a technique and preliminary results". Ultrasound in Obstetrics & Gynecology. 24 (2): 121–126. doi:10.1002/uog.1711. PMID 15287047. S2CID 72778891.
  19. Nicolaides, Kypros H. (12 January 2011). "Turning the pyramid of prenatal care". Fetal Diagnosis and Therapy. 29 (3): 183–196. doi:10.1159/000324320. PMID 21389681. S2CID 45772713.
  20. "Surgery in the womb: miracle maker for NHS's tiniest patients". The Guardian. 29 January 2016. ISSN 0261-3077. Retrieved 10 September 2017.
  21. "Erich Saling Awardee – WAPM – World Association of Perinatal Medicine".
  22. ""IAPM"".
  23. "European Association of Perinatal Medicine - EAPM". europerinatal.eu.
  24. "RCOG announcement: 2014 winner of the Eardley Holland Gold Medal". Royal College of Obstetricians & Gynaecologists.
  25. "Naguib "Mahfouz Award".
  26. "KU "Leuven".
  27. "The "Hong Kong College of Obstetricians and Gynaecologists".
  28. "Ο Κύπρος Νικολαΐδης παρασημοφορήθηκε με τον Χρυσό Σταυρό του Τάγματος του Φοίνικα (εικόνες)". antenna.gr.
  29. BBC News "Life Before Birth" for 'miracle doctor'
  30. BBC News "The Surgeon's Cut"
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