L-3-cyanoalanine synthase
The enzyme L-3-cyanoalanine synthase (EC 4.4.1.9) catalyzes the chemical reaction
- L-cysteine + hydrogen cyanide L-3-cyanoalanine + hydrogen sulfide
| L-3-cyanoalanine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.4.1.9 | ||||||||
| CAS no. | 9059-53-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide L-3-cyanoalanine-forming). Other names in common use include β-cyanoalanine synthase, β-cyanoalanine synthetase, β-cyano-L-alanine synthase, and L-cysteine hydrogen-sulfide-lyase (adding HCN). This enzyme participates in cyanoamino acid metabolism.
References
- Akopyan TN, Braunstein AE, Goryachenkova EV (1975). "β-Cyanoalanine synthase: purification and characterization". Proc. Natl. Acad. Sci. U.S.A. 72 (4): 1617–21. Bibcode:1975PNAS...72.1617A. doi:10.1073/pnas.72.4.1617. PMC 432590. PMID 1055433.
- Castric PA, Conn EE (1971). "Formation of β-cyanoalanine by O-acetylserine sulfhydrylase". J. Bacteriol. 108 (1): 132–6. doi:10.1128/jb.108.1.132-136.1971. PMC 247041. PMID 5001194.
- Hendrickson HR (1968). "The β-cyanoalanine synthase of blue lupine". Fed. Proc. 27: 593.
- Hendrickson HR, Conn EE (1969). "Cyanide metabolism in higher plants. IV. Purification and properties of the β-cyanolanine synthase of blue lupine". J. Biol. Chem. 244 (10): 2632–40. doi:10.1016/S0021-9258(18)83446-9. PMID 5769995.
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