L-olivosyl-oleandolide 3-O-methyltransferase

L-olivosyl-oleandolide 3-O-methyltransferase (EC 2.1.1.239, OleY) is an enzyme with systematic name S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + L-olivosyl-oleandolide S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide
L-olivosyl-oleandolide 3-O-methyltransferase
Identifiers
EC no.2.1.1.239
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus.

References

  1. Rodríguez L, Rodríguez D, Olano C, Braña AF, Méndez C, Salas JA (September 2001). "Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus". Journal of Bacteriology. 183 (18): 5358–63. doi:10.1128/jb.183.18.5358-5363.2001. PMC 95419. PMID 11514520.
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