L31 ribosomal protein leader
An L31 ribosomal protein leader is a ribosomal protein leader involved in ribosome biogenesis. It is used as an autoregulatory mechanism to control the concentration of the ribosomal protein L31. Five structurally distinct types of L31 ribosomal protein leader were predicted with a bioinformatic approach.[1] The structure is located in the 5′ untranslated regions of mRNAs encoding ribosomal protein L31 (rpmE),[1] and in one case L32 (rpmF). These are found in different species of Actinomycetota, Bacillota or Gammaproteobacteria. The gammaproteobacterial type was also detected and validated in an independent experimental study using the organism Escherichia coli.[2]
| Ribosomal L31 leader | |
|---|---|
 Predicted secondary structure and sequence conservation of L31_leader. This picture was adapted from a previous publication. [1] | |
| Identifiers | |
| Symbol | L31 |
| Other data | |
| RNA type | Cis-reg; leader |
| Domain(s) | Bacteria |
| PDB structures | PDBe |
References
- Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi:10.1186/s12866-020-01823-6. PMC 7247131. PMID 32448158.
- Aseev, LV; Koledinskaya, LS; Boni, IV (2 July 2020). "Autogenous regulation in vivo of the rpmE gene encoding ribosomal protein L31 (bL31), a key component of the protein-protein intersubunit bridge B1b". RNA. 26 (7): 814–826. doi:10.1261/rna.074237.119. PMC 7297116. PMID 32209634.
External links
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