LGALS3BP

Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene.[5][6][7][8]

LGALS3BP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLGALS3BP, 90K, BTBD17B, CyCAP, M2BP, MAC-2-BP, TANGO10B, gp90, galectin 3 binding protein
External IDsOMIM: 600626 MGI: 99554 HomoloGene: 4067 GeneCards: LGALS3BP
Orthologs
SpeciesHumanMouse
Entrez

3959

19039

Ensembl

ENSG00000108679

ENSMUSG00000033880

UniProt

Q08380

Q07797

RefSeq (mRNA)

NM_005567

NM_011150

RefSeq (protein)

NP_005558

NP_035280

Location (UCSC)Chr 17: 78.97 – 78.98 MbChr 11: 118.28 – 118.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Using fluorescence in–situ hybridization, the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds to galectin 1.[8]

Clinical significance

LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity.[8]

Interactions

LGALS3BP has been shown to interact with LGALS3.[7][9][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000108679 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033880 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Calabrese G, Sures I, Pompetti F, Natoli G, Palka G, Iacobelli S (May 1995). "The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25". Cytogenet Cell Genet. 69 (3–4): 223–5. doi:10.1159/000133969. PMID 7698018.
  6. Ullrich A, Sures I, D'Egidio M, Jallal B, Powell TJ, Herbst R, Dreps A, Azam M, Rubinstein M, Natoli C, et al. (Aug 1994). "The secreted tumor-associated antigen 90K is a potent immune stimulator". J Biol Chem. 269 (28): 18401–7. doi:10.1016/S0021-9258(17)32322-0. PMID 8034587.
  7. Koths K, Taylor E, Halenbeck R, Casipit C, Wang A (July 1993). "Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain". J. Biol. Chem. 268 (19): 14245–9. doi:10.1016/S0021-9258(19)85233-X. PMID 8390986.
  8. "Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein".
  9. Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S (October 1991). "Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin". J. Biol. Chem. 266 (28): 18731–6. doi:10.1016/S0021-9258(18)55124-3. PMID 1917996.
  10. Tinari N, Kuwabara I, Huflejt ME, Shen PF, Iacobelli S, Liu FT (January 2001). "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation". Int. J. Cancer. 91 (2): 167–72. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q. PMID 11146440.

Further reading


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