LIMA1

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.[5][6][7][8]

LIMA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLIMA1, EPLIN, SREBP3, LIM domain and actin binding 1, LDLCQ8
External IDsOMIM: 608364 MGI: 1920992 HomoloGene: 9484 GeneCards: LIMA1
Orthologs
SpeciesHumanMouse
Entrez

51474

65970

Ensembl

ENSG00000050405

ENSMUSG00000023022

UniProt

Q9UHB6

Q9ERG0

RefSeq (mRNA)

NM_001113546
NM_001113547
NM_001243775
NM_016357

NM_001113545
NM_023063

RefSeq (protein)

NP_001107018
NP_001107019
NP_001230704
NP_057441

NP_001107017
NP_075550

Location (UCSC)Chr 12: 50.18 – 50.28 MbChr 15: 99.68 – 99.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al., 2003).[supplied by OMIM][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000050405 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023022 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen S, Maul RS, Kim HR, Chang DD (Jul 2000). "Characterization of the human EPLIN (Epithelial Protein Lost in Neoplasm) gene reveals distinct promoters for the two EPLIN isoforms". Gene. 248 (1–2): 69–76. doi:10.1016/S0378-1119(00)00144-X. PMID 10806352.
  6. Maul RS, Chang DD (Feb 2000). "EPLIN, epithelial protein lost in neoplasm". Oncogene. 18 (54): 7838–41. doi:10.1038/sj.onc.1203206. PMID 10618726.
  7. Maul RS, Song Y, Amann KJ, Gerbin SC, Pollard TD, Chang DD (Feb 2003). "EPLIN regulates actin dynamics by cross-linking and stabilizing filaments". J Cell Biol. 160 (3): 399–407. doi:10.1083/jcb.200212057. PMC 2172667. PMID 12566430.
  8. "Entrez Gene: LIMA1 LIM domain and actin binding 1".

Further reading

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