LLGL1

Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.[5][6][7]

LLGL1
Identifiers
AliasesLLGL1, DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1, scribble cell polarity complex component, LLGL scribble cell polarity complex component 1
External IDsOMIM: 600966 MGI: 102682 HomoloGene: 31220 GeneCards: LLGL1
Orthologs
SpeciesHumanMouse
Entrez

3996

16897

Ensembl

ENSG00000284137
ENSG00000131899

ENSMUSG00000020536

UniProt

Q15334

Q80Y17

RefSeq (mRNA)

NM_004140

NM_001159404
NM_001159405
NM_008502
NM_001378836
NM_001378837

RefSeq (protein)

NP_004131

NP_001152876
NP_001152877
NP_032528
NP_001365765
NP_001365766

Location (UCSC)Chr 17: 18.23 – 18.24 MbChr 11: 60.59 – 60.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[7]

References

  1. ENSG00000131899 GRCh38: Ensembl release 89: ENSG00000284137, ENSG00000131899 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020536 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Strand D, Unger S, Corvi R, Hartenstein K, Schenkel H, Kalmes A, Merdes G, Neumann B, Krieg-Schneider F, Coy JF, et al. (Aug 1995). "A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain". Oncogene. 11 (2): 291–301. PMID 7542763.
  6. Koyama K, Fukushima Y, Inazawa J, Tomotsune D, Takahashi N, Nakamura Y (Mar 1996). "The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2". Cytogenet Cell Genet. 72 (1): 78–82. doi:10.1159/000134167. PMID 8565641.
  7. "Entrez Gene: LLGL1 lethal giant larvae homolog 1 (Drosophila)".

Further reading


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