LMO3

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.[3][4][5] LMO3 interacts with the tumor suppressor p53 and regulates its function.[6] LMO3 is considered to be an oncogene in Neuroblastoma.[7]

LMO3
Identifiers
AliasesLMO3, RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only 3
External IDsOMIM: 180386 HomoloGene: 136507 GeneCards: LMO3
Orthologs
SpeciesHumanMouse
Entrez

55885

n/a

Ensembl

ENSG00000048540

n/a

UniProt

Q8TAP4

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 12: 16.55 – 16.61 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

References

  1. GRCh38: Ensembl release 89: ENSG00000048540 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
  4. Shi J, Cai W, Chen X, Ying K, Zhang K, Xie Y (August 2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Research. 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID 11489251. S2CID 43814085.
  5. EntrezGene 55885
  6. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
  7. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.