LPXN

Leupaxin is a protein that in humans is encoded by the LPXN gene.[5][6]

LPXN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLPXN, LDPL, leupaxin
External IDsOMIM: 605390 MGI: 2147677 HomoloGene: 3536 GeneCards: LPXN
Orthologs
SpeciesHumanMouse
Entrez

9404

107321

Ensembl

ENSG00000110031

ENSMUSG00000024696

UniProt

O60711

Q99N69

RefSeq (mRNA)

NM_001143995
NM_001307951
NM_004811

NM_134152
NM_001361971

RefSeq (protein)

NP_001137467
NP_001294880
NP_004802

NP_598913
NP_001348900

Location (UCSC)Chr 11: 58.53 – 58.58 MbChr 19: 12.77 – 12.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000110031 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024696 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lipsky BP, Beals CR, Staunton DE (Jun 1998). "Leupaxin is a novel LIM domain protein that forms a complex with PYK2". J Biol Chem. 273 (19): 11709–13. doi:10.1074/jbc.273.19.11709. PMID 9565592.
  6. "Entrez Gene: LPXN leupaxin".

Further reading


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