LRIG1

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.[5][6][7] It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR family[8] and with MET[9] and RET.[10]

LRIG1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLRIG1, LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1
External IDsOMIM: 608868 MGI: 107935 HomoloGene: 7380 GeneCards: LRIG1
Orthologs
SpeciesHumanMouse
Entrez

26018

16206

Ensembl

ENSG00000144749

ENSMUSG00000030029

UniProt

Q96JA1

P70193

RefSeq (mRNA)

NM_015541

NM_008377
NM_001355269

RefSeq (protein)

NP_032403
NP_001342198

Location (UCSC)Chr 3: 66.38 – 66.5 MbChr 6: 94.58 – 94.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Model organisms

Model organisms have been used in the study of LRIG1 function. A conditional knockout mouse line, called Lrig1tm1a(EUCOMM)Wtsi[20][21] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[22][23][24]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[18][25] Twenty five tests were carried out on homozygous mutant mice and ten significant abnormalities were observed, including decreased body weight and total body fat, scaly skin, abnormal hair shedding, a moderate degree of hearing impairment, vertebral fusion, abnormal plasma chemistry and an increased susceptibility to bacterial infection (with both Salmonella and Citrobacter).[18]

References

  1. GRCh38: Ensembl release 89: ENSG00000144749 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030029 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H (Jun 2001). "Cloning, characterization, and expression of human LIG1". Biochem Biophys Res Commun. 284 (5): 1155–61. doi:10.1006/bbrc.2001.5092. PMID 11414704.
  6. Hedman H, Nilsson J, Guo D, Henriksson R (Sep 2002). "Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?". Acta Oncol. 41 (4): 352–4. doi:10.1080/028418602760169398. PMID 12234026. S2CID 34357648.
  7. "Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1".
  8. Gur G, Rubin C, Katz M, et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation". EMBO J. 23 (16): 3270–81. doi:10.1038/sj.emboj.7600342. PMC 514515. PMID 15282549.
  9. Shattuck DL, Miller JK, Laederich M, et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy". Mol. Cell. Biol. 27 (5): 1934–46. doi:10.1128/MCB.00757-06. PMC 1820466. PMID 17178829.
  10. Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G (2008). "Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF". J. Neurosci. 28 (2): 39–49. doi:10.1523/JNEUROSCI.2196-07.2008. PMC 6671136. PMID 18171921.
  11. "Body weight data for Lrig1". Wellcome Trust Sanger Institute.
  12. "Dysmorphology data for Lrig1". Wellcome Trust Sanger Institute.
  13. "DEXA data for Lrig1". Wellcome Trust Sanger Institute.
  14. "Radiography data for Lrig1". Wellcome Trust Sanger Institute.
  15. "Clinical chemistry data for Lrig1". Wellcome Trust Sanger Institute.
  16. "Salmonella infection data for Lrig1". Wellcome Trust Sanger Institute.
  17. "Citrobacter infection data for Lrig1". Wellcome Trust Sanger Institute.
  18. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  19. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  20. "International Knockout Mouse Consortium".
  21. "Mouse Genome Informatics".
  22. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  23. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  24. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  25. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

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