LRRFIP1

Leucine-rich repeat flightless-interacting protein 1 is a protein that in humans is encoded by the LRRFIP1 gene.[5][6][7][8]

LRRFIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLRRFIP1, FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP, leucine rich repeat (in FLII) interacting protein 1, LRR binding FLII interacting protein 1
External IDsOMIM: 603256 MGI: 1342770 HomoloGene: 48301 GeneCards: LRRFIP1
Orthologs
SpeciesHumanMouse
Entrez

9208

16978

Ensembl

ENSG00000124831

ENSMUSG00000026305

UniProt

Q32MZ4

Q3UZ39

RefSeq (mRNA)

NM_001137550
NM_001137551
NM_001137552
NM_001137553
NM_004735

NM_001111311
NM_001111312
NM_008515
NM_001310732

RefSeq (protein)

NP_001131022
NP_001131023
NP_001131024
NP_001131025
NP_004726

NP_001104781
NP_001104782
NP_001297661
NP_032541

Location (UCSC)Chr 2: 237.63 – 237.81 MbChr 1: 91 – 91.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

LRRFIP1 has been shown to interact with FLII.[6][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000124831 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026305 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Reed AL, Yamazaki H, Kaufman JD, Rubinstein Y, Murphy B, Johnson AC (Sep 1998). "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". J Biol Chem. 273 (34): 21594–602. doi:10.1074/jbc.273.34.21594. PMID 9705290.
  6. Liu YT, Yin HL (May 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J Biol Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.
  7. Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE (Oct 2005). "GCF2/LRRFIP1 represses tumor necrosis factor alpha expression". Mol Cell Biol. 25 (20): 9073–81. doi:10.1128/MCB.25.20.9073-9081.2005. PMC 1265793. PMID 16199883.
  8. "Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1".
  9. Fong KS, de Couet HG (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.

Further reading


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