LRRFIP1

LRRFIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H22
Identifiers
Aliases	LRRFIP1, FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP, leucine rich repeat (in FLII) interacting protein 1, LRR binding FLII interacting protein 1
External IDs	OMIM: 603256 MGI: 1342770 HomoloGene: 48301 GeneCards: LRRFIP1
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	237,813,682 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	91,128,944 bp[2]
RNA expression pattern
	Top expressed in
	renal medulla; ; endothelial cell; ; cardia; ; nipple; ; pylorus; ; visceral pleura; ; superior surface of tongue; ; pericardium; ; ventral tegmental area; ; trigeminal ganglion;
	Top expressed in
	secondary oocyte; ; conjunctival fornix; ; urothelium; ; hair follicle; ; lacrimal gland; ; salivary gland; ; parotid gland; ; left lung lobe; ; medullary collecting duct; ; ciliary body;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; double-stranded RNA binding; protein binding; protein homodimerization activity; cadherin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	plasma membrane; cytoskeleton; nucleus; cytoplasm; cytosol;
Biological process	regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; positive regulation of type I interferon production; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	9208
	16978
	ENSG00000124831
	ENSMUSG00000026305
	Q32MZ4
	Q3UZ39
	NM_001137550; NM_001137551; NM_001137552; NM_001137553; NM_004735
	NM_001111311; NM_001111312; NM_008515; NM_001310732
	NP_001131022; NP_001131023; NP_001131024; NP_001131025; NP_004726
	NP_001104781; NP_001104782; NP_001297661; NP_032541
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat flightless-interacting protein 1 is a protein that in humans is encoded by the LRRFIP1 gene.[5][6][7][8]

Interactions

LRRFIP1 has been shown to interact with FLII.[6][9]

References

GRCh38: Ensembl release 89: ENSG00000124831 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026305 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Reed AL, Yamazaki H, Kaufman JD, Rubinstein Y, Murphy B, Johnson AC (Sep 1998). "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". J Biol Chem. 273 (34): 21594–602. doi:10.1074/jbc.273.34.21594. PMID 9705290.
Liu YT, Yin HL (May 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J Biol Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.
Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE (Oct 2005). "GCF2/LRRFIP1 represses tumor necrosis factor alpha expression". Mol Cell Biol. 25 (20): 9073–81. doi:10.1128/MCB.25.20.9073-9081.2005. PMC 1265793. PMID 16199883.
"Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1".
Fong KS, de Couet HG (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.

Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
Khachigian LM, Santiago FS, Rafty LA, Chan OL, Delbridge GJ, Bobik A, Collins T, Johnson AC (1999). "GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury". Circ. Res. 84 (11): 1258–67. doi:10.1161/01.res.84.11.1258. PMID 10364563.
Fong KS, de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.
Rikiyama T, Curtis J, Oikawa M, Zimonjic DB, Popescu N, Murphy BA, Wilson MA, Johnson AC (2003). "GCF2: expression and molecular analysis of repression". Biochim. Biophys. Acta. 1629 (1–3): 15–25. doi:10.1016/s0167-4781(03)00156-8. PMID 14522076.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124831 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026305 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9705290-5] Reed AL, Yamazaki H, Kaufman JD, Rubinstein Y, Murphy B, Johnson AC (Sep 1998). "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". J Biol Chem. 273 (34): 21594–602. doi:10.1074/jbc.273.34.21594. PMID 9705290.

[pmid9525888-6] Liu YT, Yin HL (May 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J Biol Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.

[pmid16199883-7] Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE (Oct 2005). "GCF2/LRRFIP1 represses tumor necrosis factor alpha expression". Mol Cell Biol. 25 (20): 9073–81. doi:10.1128/MCB.25.20.9073-9081.2005. PMC 1265793. PMID 16199883.

[entrez-8] "Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1".

[pmid10366446-9] Fong KS, de Couet HG (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.

LRRFIP1

Interactions

References

Further reading